Research Lab Technician II - OHNS Cancer Research

Site:
Massachusetts Eye and Ear Infirmary

Mass General Brigham relies on a wide range of professionals, including doctors, nurses, business people, tech experts, researchers, and systems analysts to advance our mission. As a not-for-profit we support patient care, research, teaching, and community service, striving to provide exceptional care. We believe that high-performing teams drive groundbreaking medical discoveries and invite all applicants to join us and experience what it means to be part of Mass General Brigham.

Carries out a broad range of technically advanced research activities and procedures; evaluates conclusions and has considerable latitude to modify or devise methods and techniques as necessary to achieve desired results; typically supervises technical and sometimes administrative elements of the research unit.

Does this position require Patient Care? No

• Executes protocols of non-routine experiments.
• Assists PI with determining the most suitable methodology.
• Performs basic design and modification of protocols.
• Calculates, transcribes, and analyzes data.
• Prepares and presents reports.
• Organizes and summarizes acquired data using scientific and Statistical Techniques.
• Participates in the design of experiments or field work.

Education
Bachelor's Degree related field of study required

Can this role accept experience in lieu of a degree? Yes

Licenses and Credentials

Experience
Previous research lab experience 1‑2 years required

Knowledge,

Skills and Abilities

• Analytical skills and ability to resolve technical problems.
• Ability to interpret acceptability of data results.
• Strong computer skills.
• Demonstrated competence in research techniques and methodologies.

Job Description:

Research Lab Technician II (RLT II)

Under the direction of the Principal Investigator, the Research Technician II will support preclinical and translational cancer research within the Department of Otolaryngology–Head and Neck Surgery at Mass Eye and Ear. The position is based in the research space at SERI, 50 Staniford Street, Boston, under the supervision of Dr. Rahul Pal. The technician will play a central role in maintaining and executing in vivo mouse tumor studies and associated cellular and molecular biology experiments.

A strong foundation in animal handling, cell biology, and standard molecular biology techniques is essential. This position is well suited for a candidate interested in applying rigorous biological methods to translational cancer research, with opportunities to learn and grow into cutting edge imaging and computational analysis approaches developed in the laboratory.

• Establishing, maintaining, and monitoring murine tumor models
• Performing tumor implantation, measurements, and longitudinal study support
• Handling and processing of mouse tissues following in vivo experiments
• Supporting ex vivo tissue preparation and analysis, including sample preservation for downstream assays

• Maintaining routine mammalian cell culture
• Establishing and expanding primary cell lines from tumor or tissue specimens
• Performing cell-based assays to evaluate biological responses to therapeutic or imaging agents
• Supporting experimental design and execution of mechanistic studies in vitro

• Tissue processing for downstream molecular analyses
• Extraction of DNA, RNA, and proteins from tissue and cell samples
• Western blotting, immunodetection, and related protein analysis techniques
• Flow cytometry and sample preparation for immune and tumor cell profiling
• Supporting downstream data interpretation in collaboration with investigators

• Participation in ex vivo tissue imaging and fluorescence-based assays
• Exposure to advanced fluorescence lifetime imaging and other optical imaging modalities developed in the laboratory
• Assisting with instrument testing, validation, and experimental imaging workflows
• Imaging expertise is not required at entry level and will be developed through on-the-job training