Scientist – RNA Sequencing​/ddPCR

Scientist – RNA Sequencing / ddPCR

Position:
Full-Time;
Monday – Friday; 8am-5pm EST

This is a fully onsite role based at our customer's site in (insert location – i.e. Boston, MA). We welcome applicants from all locations within the US.

Must be legally authorized to work in the United States without sponsorship.

Must be able to pass a comprehensive background check, which includes a drug screening.

At Thermo Fisher Scientific, you'll discover meaningful work that makes a positive impact on a global scale. Join our colleagues in bringing our Mission to life - enabling our customers to make the world healthier, cleaner and safer.

Thermo Fisher's clinical research business is a leading global contract research organization and world leader in serving science. We are passionate, deliberate, and driven by our mission – to enable our customers to make the world healthier, safer, and cleaner.

Our Laboratories Functional Service Partnership (FSP) team plays a direct role in advancing drug development by creating sustained groups of talent within our customers' organizations to provide long-term support.

Key responsibilities:

• Independently design, execute, troubleshoot, optimize, and interpret analytical method development experiments using digital PCR, qPCR, ddPCR, bulk RNA sequencing
• Nano String nCounter, Oxford Nanopore sequencing NICE TO HAVE
• Perform DNA/RNA extraction, sequencing library preparation, sequencer operation, digital PCR workflows, and other associated laboratory procedures with a high standard of technical rigor.
• Design and conduct experiments to evaluate assay performance characteristics, including accuracy, precision, linearity, sensitivity, and technology comparisons.
• Analyze and interpret data using R, Graph Pad Prism, JMP, and related bioinformatics tools to support assay development, process characterization, and technology evaluation.
• Organize, analyze, and summarize data for project updates, technical reports, study summaries, and internal presentations.
• Author and review protocols, SOPs, technical reports, study documentation, and regulatory support documents.
• Collaborate cross-functionally with partners in analytical development, process development, research, and other teams to support analytical strategy and project goals.
• Operate, maintain, and troubleshoot laboratory instrumentation, including Next Seq 2000, Nova Seq X, PromethION 24, Nano String nCounter Prep Station/Digital Analyzer, and digital PCR platforms.
• Maintain laboratory organization, instrument readiness, reagent inventory, and compliance with documentation and laboratory best practices.

Education and Experience:

• Bachelor's degree in lab sciences such as Chemistry, Biochemistry, Material Science, Immunology, Biology, Molecular Biology or similar
• Scientist:
  Previous experience that provides the knowledge, skills, and abilities to perform the job (comparable to 2+ years')
• OR Masters degree

In some cases, an equivalency, consisting of a combination of appropriate education, training and/or directly related experience, will be considered sufficient for an individual to meet the requirements of the role.

Knowledge, Skills and Abilities:

• Digital PCR (ddPCR, dPCR)
• qPCR
• Nano String nCounter (NICE TO HAVE)
• Bulk RNA-sequencing library preparation and sequencing
• DNA/RNA extraction
• Oxford Nanopore library preparation and sequencing workflows
• Statistical analysis and data visualization using R, Graph Pad Prism, JMP, and Microsoft Excel
• Differential gene expression analysis using DESeq2
• Pathway enrichment analysis using GSEA and Gene Ontology
• Sequencing data quality control, interpretation, and reporting
• Analysis of digital PCR and sequencing datasets to support method development and process characterization
• Proficiency with Microsoft PowerPoint, Excel, and Word

Working Environment:

Below is listed the working environment/requirements for this role:

Able to communicate, receive, and understand information and ideas with diverse groups of people in a comprehensible and reasonable manner.

Able to work upright and stationary and/or standing for typical working hours.

Able to lift and move objects up to 25 pounds

Able to work in non-traditional work…