Associate Director, Clinical Operations

Company Overview

Kymera is a clinical‑stage biotechnology company pioneering targeted protein degradation (TPD) to develop medicines that address critical health problems and dramatically improve patients’ lives. The company is building an industry‑leading pipeline of oral small molecule degraders. Founded in 2016, Kymera has been recognized as one of Boston’s top workplaces. Learn more at

• PIONEER: We are courageous, resilient and rigorous in our mission to improve patients’ lives through our revolutionary degrader medicines.
• COLLABORATE: We value trust and transparency from everyone. Our goals are shared, our decisions data‑driven and our camaraderie genuine.
• BELONG: We recognize our differences, inviting curiosity and inclusivity, so that our people are valued, seen, and heard.

• Contribute to the planning, implementation, and execution of global clinical trials.
• Plan, execute, and lead study‑specific meetings (e.g., internal core team meetings, investigator meetings, etc.), as needed.
• Provide input for the design of the Informed Consent Form(s), eCRFs, monitoring conventions, edit checks, etc.
• Provide study‑specific training and leadership to clinical research staff, CRO, CRAs, sites and other contract personnel.
• Manage study timelines and metrics to ensure completion of study deliverables.
• Lead site feasibility and selection qualification, initiation, and oversight of outsourced monitoring activities.
• Review monitoring reports to ensure quality and resolution of site‑related issues.
• Ensure timely enrollment and data collection at clinical trial sites.
• Collaborate with the data management team to ensure data integrity and timely database lock.
• Ensure tracking, review of protocol deviations, and assess impact on study data.
• Work closely with translational medicine team to ensure appropriate incorporation of bioanalytical sampling plan into clinical protocols and relevant data output of the trial is provided to functional groups for review.
• Partner with Operational Excellence and assigned Site Engagement Leads to help drive site engagement and bolster recruitment.
• Serve as key counterpart of Clinical Outsourcing to build RFPs and support the selection of clinical vendors.
• Oversee and contribute to Sponsor Oversight activities including but not limited to review of KPIs, KRIs, PDs, risks, Data Review Findings, etc. to assess the health of the study and proactively ensure mitigations are in place to achieve Kymera’s quality standards.
• Contribute to clinical operations process improvement initiatives.
• Maintain accurate and complete trial documentation.
• Proactively identify and resolve clinical project issues.
• This role may require up to 25% travel.

• BS degree and 8+ years of experience in clinical operations in biotech/pharma, including 5 years leading global clinical trials.
• Inspection readiness experience preferred.
• Experience working on large, global, complex phase 2b/3 or late‑stage trials. Respiratory or immunology experience highly preferred.
• Broad knowledge of global regulations and guidelines including CFR, ICH GCP, HIPAA, GDPR, and the Protection of Human Research Subjects.
• Strong project management skills with the ability to manage multiple trials simultaneously.
• Excellent problem‑solving, leadership, and communication skills.
• Ability to work in a fast‑paced, dynamic environment with cross‑functional teams.

Kymera Therapeutics is proud to be an equal‑opportunity employer, seeking to create a welcoming and diverse environment. All applicants will receive consideration for employment without regard to race, color, religion, creed, gender, national origin, age, disability, veteran status, pregnancy, sex, marital status, gender expression or identity, genetic information, sexual orientation, citizenship, or any other legally protected class.

• Kymera offers a competitive compensation package that recognizes both results and capabilities through market‑based, performance‑driven pay.
• The anticipated base salary range for this role is $160,000 – $240,000, with eligibility for annual bonus, equity participation, and comprehensive benefits.
• Actual salary is based on a holistic evaluation of the specific role/level as well as each candidate’s depth of experience and the capabilities they bring to the position.