Raven StealthCo- Principal Scientist, Analytical Chemistry

Position

The Principal Scientist, Analytical Chemistry will report directly to the Director of Oligonucleotide and Conjugation Chemistry and will interface frequently with members of the delivery group and cross-functional teams to advance oligonucleotide therapeutic programs. This individual will help define and execute the strategy to analyze oligonucleotides and conjugates in an efficient and timely manner. As a lab-based role, this person will assist in the implementation and use of scientific and analytical equipment to yield high-quality oligonucleotide and oligonucleotide‑conjugate materials.

• Define and implement reproducible analytical protocols to characterize oligonucleotides for biological evaluation in our targeted delivery platform
• Develop and implement QC methods to determine purity, composition, and concentration of oligonucleotides and conjugates using a toolbox of analytical methods (HPLC, MS, (bio) analytical assays, etc.)
• Develop and implement analytical methods (e.g., MS) to determine drug‑to‑conjugate ratios of antibody‑oligonucleotide conjugates
• Develop and implement analytical methods to determine in‑vitro stability (e.g., serum stability) of oligonucleotides and conjugates
• In conjunction with the biology group, assist in development and implementation of analytical methods to determine pharmacokinetics and distribution of oligonucleotides and conjugates in vivo
• Assist in internal lab build, procuring and utilizing analytical equipment to characterize oligonucleotides and antibody/peptide‑oligonucleotide conjugates
• Assist conjugation scientists in developing methods (SEC, IEX, etc.) to purify oligonucleotide conjugates

• PhD in chemistry or related discipline with 5+ years of experience working with oligonucleotide therapeutics (siRNA, ASOs, etc.) in the biopharmaceutical industry; or BS/MS with 10+ years
• Ideal candidate will have experience analyzing peptide-, protein-, or antibody‑oligonucleotide conjugates, effectively operating in a cross‑functional, collaborative environment
• Adept in state‑of‑the‑art analytical methods (SEC, IEX, RP‑HPLC, MS, etc.) to characterize oligonucleotide conjugates
• Experience in (bio) analytical assays to determine pharmacokinetic, distribution, and PD profiles of oligonucleotide therapeutics is a plus
• While demonstrating creativity to contribute to the development of novel delivery systems, this individual must also be process‑ and detail‑oriented to ensure proper release of high‑quality oligonucleotide material for in‑vivo testing
• Imperative that this individual be an effective communicator and proven team‑player, with the ability to operate independently in a laboratory setting

Base salary range: $160,000 – $190,000 USD. The role may also be eligible for an annual bonus and long‑term incentives. Compensation and benefits may be updated in the future.