Preclinical In Vivo Associate II

Preclinical In Vivo Associate II

We are seeking a highly motivated individual to join a preclinical in vivo pharmacology associates' team in a fast-paced and collaborative environment at the Experimental Therapeutics Core Facility at Dana-Farber Cancer Institute. The individual will work closely with the preclinical and clinical scientists at the Institute and leading industry collaborators to design and execute oncology-related mouse studies. Individuals will have access to extensive training in mouse handling and in vivo skills necessary for procedures to participate in the preclinical research setting actively.

Studies focus on cancer model development and testing a variety of novel cancer therapies by monitoring in vivo disease progression through various modalities- like bioluminescence imaging, flow cytometry, or caliper measurement. Studies run through the Experimental Therapeutics Core lead to further world-class research or high-ranked publications. A successful candidate requires the ability to organize and manage a workload independently while aiding team members in building a collaborative environment.

They would need to keep detailed, accurate records of completed studies to report findings to investigators, resulting in further research or publication.

The Preclinical In Vivo Associate II will perform scientific research, which includes design and execute oncology related mouse studies using bioluminescence (BLI) imaging as well as the entire spectrum of conventional (e.g., caliper measurements, clinical scoring) endpoints to evaluate pre-clinical novel cancer therapies. They will perform set up, operation and maintenance of laboratory instruments and equipment, monitoring experiments, making observations, and calculating and recording results to meet the requirements of industry sponsored research agreements.

They must maintain a professional demeanor in communications with collaborators. They must be able to take the necessary initiative to meet project timelines and deliverables. Must be able to understand and follow the Animal Resource Facilities standard operating procedures and institutional guidelines and policies and local, state, federal and regulations and guidelines for working with in vivo research models.

Located in Boston and the surrounding communities, Dana-Farber Cancer Institute is a leader in life changing breakthroughs in cancer research and patient care. We are united in our mission of conquering cancer, HIV/AIDS, and related diseases. We strive to create an inclusive, diverse, and equitable environment where we provide compassionate and comprehensive care to patients of all backgrounds, and design programs to promote public health particularly among high-risk and underserved populations.

We conduct groundbreaking research that advances treatment, we educate tomorrow's physician/researchers, and we work with amazing partners, including other Harvard Medical School-affiliated hospitals.

• Routine handling, restraint, identification (including ear notching and tattooing) of mice or rats.
• Establish and maintain mouse and rat cancer models to test efficacy, tolerability, and PK/PD of novel therapeutics.
• Independently execute in vivo studies by dosing therapeutics agents by various routes (e.g., oral gavage, intraperitoneal, intravenous)
• Monitor cancer progression through bioluminescence imaging, flow cytometry, or caliper measurements.
• Perform blood drawings, necropsies, and process ex vivo samples.
• Mammalian cell culture and maintenance of cell lines.
• Interpret, present, and document experiments based on data generated to investigators, often leading to further experiments or publications.
• Responsible for maintaining and reporting accurate records of inventory/ equipment.
• Follow IACUC requirements (animal standard operating procedures) and DFCI institutional guidelines and policies.
• Provide any necessary training and support to staff members. Work within a team environment, while maintaining independent responsibilities. Mentor team members and take on project leadership responsibilities.
• Acts independently to determine methods and procedures for new or…