Analytical Development Senior Scientist

Job Description General Summary Vertex is seeking a Senior Research Scientist to join Analytical Development in Boston, MA. This role supports the advancement of transformative medicines by leading analytical chemistry activities across all stages of clinical development. The position is part of the Chromatography Subject Matter Expert (SME) team, focused on small molecules and synthetic peptides/oligonucleotides, with particular emphasis on drug substance, drug product intermediates, and drug product.

• Lead chromatographic method development, qualification, and validation activities.
• Partner with cross-functional project teams to design, oversee, and review analytical methods, validation protocols, and reports.
• Serve as a technical expert in chromatographic instrumentation and method development, including specialized detectors, column screening, forced degradation, and robustness studies.
• Drive continuous improvement in phase-appropriate analytical development and validation practices.
• Ensure consistent, compliant method development and validation practices across the organization.
• Design and execute complex, technically challenging experiments that support departmental and project goals.
• Interpret data, draw evidence-based conclusions, and assess broader implications of findings.
• Develop innovative solutions to technical challenges and provide scientific guidance to team members when needed.
• Contribute meaningfully to project strategy and critical scientific activities within the discipline.
• Help build organizational capability through staff training, mentorship, and knowledge sharing.
• Apply concepts or approaches from other fields to advance scientific progress.
• Perform other duties as assigned.

• Deep experience in analytical method development and validation.
• Strong technical expertise in chromatography and related analytical techniques, including GC, LC, GC-MS, LC-MS, Karl Fischer, and spectroscopy.
• Proven ability in troubleshooting, data review, and interpretation.
• Strong understanding of pharmaceutical industry regulations, guidelines, and GMP practices.
• Excellent organizational, project management, written, and verbal communication skills.
• Ability to explain technical concepts clearly and influence diverse stakeholders.
• Effective in both team-based/matrix environments and independent work.
• Able to manage multiple priorities in a fast‑paced environment while maintaining timelines and quality.
• Strong attention to detail.
• Demonstrated ability to mentor others, advance projects through scientific insight, and identify productive new experimental approaches.

Ph.D. with 2+ years or Master’s degree with 5+ years of relevant analytical development experience. Exceptional candidates with a B.S. degree with 8+ years of advanced industry experience will also be considered.

Pay Range: $122,400 - $183,600

The range provided is based on what we believe is a reasonable estimate for the base salary pay range for this job at the time of posting. This role is eligible for an annual bonus and annual equity awards. Some roles may also be eligible for overtime pay, in accordance with federal and state requirements. Actual base salary pay will be based on a number of factors, including skills, competencies, experience, and other job-related factors permitted by law.

At Vertex, our Total Rewards offerings also include inclusive market-leading benefits to meet our employees wherever they are in their career, financial, family and wellbeing journey while providing flexibility and resources to support their growth and aspirations. From medical, dental and vision benefits to generous paid time off (including a week-long company shutdown in the Summer and the Winter), educational assistance programs including student loan repayment, a generous commuting subsidy, matching charitable donations, 401(k) and so much more.

On-Site Designated Flex Eligibility Status:
In this On-Site designated role, you will work five days per week on-site with ad hoc flexibility.

Note:

The Flex status for this position is subject to Vertex’s Policy…