Postdoctoral Research Fellow

Postdoctoral Research Fellow

The Miller Laboratory at the Massachusetts General Hospital Center for Systems Biology is recruiting a full-time Postdoctoral Research Fellow. The Miller Laboratory for Precision Therapeutics develops new chemical and nanotechnology-based approaches for spatially controlled cancer therapy. Our research combines organic synthesis, bioconjugate chemistry, drug delivery, molecular imaging, cancer biology, immunology, and quantitative tissue analysis to understand and engineer how therapeutics behave within tumors.

The successful candidate will lead projects involving radiation-activated chemistry, drug conjugates, and externally triggered therapeutic systems. Research may include the design and organic synthesis of radiation-responsive linkers and prodrugs; development of antibody, protein, polymer, or nanoparticle conjugates; investigation of radiation-mediated payload activation; and characterization of new compounds using HPLC, LC–MS, NMR spectroscopy, and related analytical methods.

Projects may also incorporate radiopharmaceuticals, ultrasound-responsive drug delivery, bioorthogonal chemistry, molecular imaging, and studies of the tumor immune microenvironment. Therapeutic distribution and response may be evaluated using preclinical tumor models, multiplex tissue imaging, flow cytometry, single-cell analysis, and spatial-omics techniques. The fellow will work within a multidisciplinary environment and collaborate with chemists, cancer biologists, immunologists, engineers, imaging scientists, radiation oncologists, and other physician-scientists across Massachusetts General Hospital and the broader Harvard research community.

Education

PhD or equivalent doctoral degree in organic chemistry, chemical biology, biological chemistry, medicinal chemistry, materials chemistry, bioengineering, or a related discipline.

Experience

• Strong hands-on experience in organic synthesis and/or bioconjugate chemistry.
• Experience in at least one additional relevant area, such as nanoparticle formulation, polymer chemistry, medicinal chemistry, biomaterials, or drug delivery.
• Ability to work effectively both independently and as part of a multidisciplinary research team.
• Candidates who expect to complete their doctoral degree before the anticipated start date are encouraged to apply.

Knowledge,

Skills and Abilities

• Experience in one or more of the following areas is beneficial:
• Antibody–drug, protein–drug, or polymer–drug conjugates.
• Stimuli-responsive or activatable chemistry.
• Nanoparticle formulation and physicochemical characterization.
• Radiochemistry and radiopharmaceuticals.
• Cancer biology, tumor models, or cancer immunology.
• Molecular imaging and microscopy.
• Ultrasound-responsive materials or drug-delivery systems.
• Pharmacology, pharmacokinetics, or biodistribution.
• Flow cytometry, multiplex tissue imaging, single-cell sequencing, or spatial omics.

Applicants are not expected to have experience in all of these areas. Candidates with strong chemistry backgrounds who are interested in expanding into cancer biology, imaging, immunology, and translational therapeutics are particularly encouraged to apply.

Additional Job Details (if applicable)

The salary for this position ranges from $70,000 to $71,750.

To apply for this position,  and cover letter directly to Miles Miller lerVARD.EDU.

Remote Type:
Onsite

Work Location:

185 Cambridge Street

EEO Statement: 1300 Massachusetts General Physicians Organization, Inc. is an Equal Opportunity Employer. All qualified applicants will receive consideration for employment without regard to race, color, religious creed, national origin, sex, age, gender identity, disability, sexual orientation, military service, genetic information, and/or other status protected under law. We will ensure that all individuals with a disability are provided a reasonable accommodation to participate in the job application or interview process, to perform essential job functions, and to receive other benefits and privileges of employment.

To ensure reasonable accommodation for individuals protected by Section 503 of the Rehabilitation Act of 1973, the Vietnam Veteran's Readjustment Act of 1974, and Title I of the Americans with Disabilities Act of 1990, applicants who require accommodation in the job application process may contact Human Resources at .