Scientist, In Vivo Pharmacology

Key Responsibilities In vivo study execution

• Establish and run CDX efficacy studies — tumor cell preparation and implantation (subcutaneous and, where relevant, orthotopic), enrollment, randomization, and study monitoring.
• Administer test articles by multiple routes (IV, IP, SC) with accurate dosing, and maintain precise dosing records.
• Collect tumor-volume and body-weight measurements on schedule, monitor animal health, and recognize and elevate clinical observations promptly.
• Perform terminal procedures and collect blood and tissue samples for PK, PD, and biomarker analysis.

• Design and execute dose-range-finding (DRF) studies to define active and tolerated dose levels for ADC candidates.
• Run dose-fractionation studies that compare dose level versus schedule, helping distinguish exposure-driven from schedule-driven activity and tolerability.
• Partner with the Director and DMPK to align dosing and sampling schedules so efficacy, exposure, and tolerability read out cleanly from the same study.

• Record, plot, and summarize tumor-growth and body-weight data; generate clear growth curves and study summaries.
• Maintain meticulous study documentation and data integrity, and follow all IACUC protocols and animal-welfare requirements.
• Manage study logistics — cell-line readiness, animal ordering and acclimation, dosing formulations, and scheduling.
• Contribute to SOPs and help improve in vivo workflows and reproducibility.

• BS with 4+ years, or MS with 2+ years, of hands‑on in vivo oncology experience in a biotech, pharma, or CRO setting.
• Demonstrated proficiency in rodent handling, tumor implantation, multi-route dosing (IV/IP/SC), tumor measurement, and terminal procedures.
• Experience running xenograft (CDX) efficacy studies and collecting PK/PD samples.
• Strong record‑keeping, attention to detail, and comfort with data entry and basic analysis (e.g., Excel, Graph Pad Prism).
• Current or obtainable IACUC training and a genuine commitment to animal welfare.