Postdoctoral Research Fellow - Reinherz Lab

Postdoctoral Research Fellow - Reinherz Lab Dana-Farber Cancer Institute Boston, Ma Full Time Overview

The Reinherz lab at Dana-Farber Cancer Institute and Harvard Medical School is recruiting a postdoctoral fellow to study HIV-1 vaccine immunology. We use an interdisciplinary approach combining structural biology, molecular biology, biochemistry, and immunology to generate insights that can be translated into HIV-1 vaccine design. Specific research areas of interest include molecular and cellular mechanisms underlying B cell immunodominance and strategies to modulate B cell affinity maturation during vaccination to induce protective immunity while preventing induction of autoimmunity.

The laboratory provides a rich training environment and access to cutting-edge techniques.

Located in Boston and the surrounding communities, Dana-Farber Cancer Institute is a leader in life changing breakthroughs in cancer research and patient care. We are united in our mission of conquering cancer, HIV/AIDS, and related diseases. We strive to create an inclusive, diverse, and equitable environment where we provide compassionate and comprehensive care to patients of all backgrounds, and design programs to promote public health particularly among high-risk and underserved populations.

We conduct groundbreaking research that advances treatment, we educate tomorrow'sphysician/researchers,and we work with amazing partners, including other Harvard Medical School-affiliated hospitals.

• Conduct research focused on
  HIV-1 Env vaccine development
  and the
  modulation of B cell affinity maturation
  .
• Contribute to
  structure-guided immunogen design
  and the development of
  novel vaccine strategies
  to improve subdominant antibody responses.
• Work in a collaborative research environment while independently driving experimental projects.

• Design and execute studies related to
  HIV-1 Env vaccine candidates
  .
• Investigate approaches to enhanceB cell affinity maturation
  and antibody responses.
• Perform
  mouse immunization studies
  and related in vivo experimental work.
• Analyze
  immune sera
  to assess vaccine-elicited responses.
• Conduct
  flow cytometry (FACS)for immune cell characterization and analysis.
• PerformB cell repertoire analysis
  and
  immunohistology
  experiments.
• Carry out
  molecular cloning
  ,
  protein expression
  , and
  protein purification
  .
• Maintain and utilize
  cell culture systems
  to support research activities.
• Interpret experimental data, prepare reports, and contribute to manuscripts for publication.
• Collaborate effectively with other lab members and support broader research goals.

• Recent
  PhD
  or
  MD/PhD
  in
  biomedical sciences
  or a closely related field.
• Strong background in
  immunology
  ,
  molecular biology
  , and
  biochemistry
  .
• Hands-on experience with techniques used to evaluate immune responses, including:
  • Antibody measurement
  • B cell and T cell response analysis
  • B cell repertoire analysis
  • Mouse models and animal handling
• Demonstrated publication record in
  peer-reviewed journals
  .
• Excellent
  written and verbal communication skills
  .
• Ability to work
  independently
  as well as collaboratively in a team setting.

• Experience with
  molecular cloning
  and related molecular biology techniques.
• Proficiency in
  protein expression
  ,
  protein purification
  , and
  biochemical methods
  .
• Experience with
  cell culture
  techniques.
• Strong organizational skills and the ability to manage multiple projects.

Applicants should submit:

• A
  CV
• A brief
  statement of research interests/goals
• Three professional references

At Dana-Farber Cancer Institute, we work every day to create an innovative, caring, and inclusive environment where every patient, family, and staff member feels they belong. As relentless as we are in our mission to reduce the burden of cancer for all, we are committed to having faculty and staff who offer multifaceted experiences. Cancer knows no boundaries and when it comes to hiring the most dedicated and compassionate professionals, neither do we.

Dana-Farber Cancer Institute is an equal opportunity employer and affirms the right of every qualified applicant to receive consideration for employment without regard to race, color, religion, sex, gender identity or expression, national origin, sexual orientation, genetic information, disability, age, ancestry, military service, protected veteran status, or other characteristics protected by law.

The hiring range is based on market pay structures, with individual salaries determined by factors such as business needs, market conditions, internal equity, and based on the candidate’s relevant experience, skills and qualifications.

For union positions, the pay range is determined by the Collective Bargaining Agreement (CBA).

$72,000.00 - $76,385.00