Sr. Scientist, Neuroimmunology

Job Description

Location:

Boston, MA

We are seeking a highly motivated, laboratory-based scientist to join the Neuroimmunology team at our Company. This role is ideal for a hands-on experimentalist with expertise in preclinical models, neuroimmunology, neurodegeneration, and translational biology. The successful candidate will independently design and execute in vivo studies, generate mechanistic insights into microglial biology, and contribute to the discovery of novel therapies for CNS diseases.

• Play a key role in supporting pipeline programs by designing and executing studies, interpreting complex datasets, and communicating findings to cross-functional teams
• Serve as a hands-on scientist conducting in vivo procedures and downstream analyses
• Generate and interpret pharmacology, efficacy, biomarker, and mechanistic datasets to support target validation and drug discovery programs
• Perform CNS immune cell isolation, flow cytometry, immunophenotyping, molecular profiling, and histological analyses
• Collaborate with multidisciplinary teams across pharmacology, immunology, chemistry, biologics, biomarker sciences, and data science
• The individual is expected to provide scientific leadership, contribute to program strategy, and influence decision-making through data-driven recommendations

• Education and experience:
  
  PhD in Neuroscience, Immunology, Cell Biology, Pharmacology, Bioengineering, Neurology, or a related STEM field; postdoctoral industry experience preferred. OR Master's degree in Neuroscience, Immunology, Cell Biology, Pharmacology, Bioengineering, Neurology, or a related STEM field with Minimum 6+ years of pharmaceutical or biotechnology industry experience.
• Required Skills:
  • Extensive hands-on experience with rodent in vivo studies
  • Experience with mouse models of neurodegeneration, neuroinflammation, or CNS disease
  • Expertise in flow cytometry, CNS immune cell isolation, immunohistochemistry, and molecular biology techniques
  • Familiarity with omics approaches (RNA-seq, single-cell technologies) and data analysis
  • Strong experimental design, statistical analysis, and problem-solving skills
  • Excellent communication and collaboration skills in a cross-functional research environment

• Industry experience supporting discovery or early development programs in CNS disorders
• Experience with Alzheimer's disease, Parkinson's disease, ALS, multiple sclerosis, or related neurodegenerative diseases
• Hands-on experience with transgenic rodent models, including behavioral, pharmacology, and biomarker studies
• Experience with primary microglia cultures, macrophages, immune cell assays, or iPSC-derived CNS cell systems
• Familiarity with translational biomarkers, PK/PD relationships, and mechanism-based drug development
• Experience working within multidisciplinary drug discovery teams and advancing programs from target validation through candidate selection
• Prior experience leading collaborative projects, in particular, the ability to coordinate activities across multiple functions will be an important consideration

• Animal Models
• Assay Development
• Biochemical Assays
• Cell Culture Techniques
• Flow Cytometry
• Immunoassays
• Immunology
• In Vivo Models
• Mouse Handling
• Neuroanatomy
• Neurodegeneration
• Neuroimmunology
• Omics
• Pharmacodynamics
• Transcriptomics

Our company is committed to inclusion, ensuring that candidates can engage in a hiring process that exhibits their true capabilities.

As an Equal Employment Opportunity Employer, we provide equal opportunities to all employees and applicants for employment and prohibit discrimination on the basis of race, color, age, religion, sex, sexual orientation, gender identity, national origin, protected veteran status, disability status, or other applicable legally protected characteristics. As a federal contractor, we comply with all affirmative action requirements for protected veterans and individuals with disabilities.

For more information about personal rights under the U.S. Equal Opportunity Employment laws, visit: EEOC Know Your Rights EEOC GINA Supplement. We are proud to be a company that…