Research Fellow Center Genomic Medicine

Post-Doctoral Research Fellow

The Musolino Laboratory in the Center for Genomic Medicine at the Massachusetts General Hospital, Harvard Medical School, is seeking highly motivated post-doctoral Research Fellow candidates. At the Musolino laboratory we are dedicated to the development and application of innovations in gene therapy technologies for rare vascular conditions.

Principal Duties And Responsibilities:

• Perform CRISPR-based genome editing using established protocols
• Perform molecular genomics procedures as needed (i.e., DNA/RNA extraction, library production, RNAseq, sample archiving, tissue culture, etc.)
• Design, execute, and interpret research experiments
• Learn any number of molecular genomics techniques including single-cell RNAseq (scRNAseq), ATACseq, ChIPseq, HiC, and other methods
• Routinely check medium, reagents, and plastic wares for cell culture experiments
• Maintain mouse colonies and process murine tissues for phenotypic evaluation
• Perform noninvasive and invasive hemodynamic assessments of mouse models of human disease
• Maintain laboratory notebook
• Independently follow detailed protocols while working closely with a wide range of lab members (i.e., graduate students, postdocs, technicians, staff scientists)
• Assist in training new Research Technicians and Fellows
• Responsible for troubleshooting problems and instructing others in highly specialized techniques.
• Investigate, create, and develop new methods and technologies for research advancements.
• Preparation of written data reports, including methodology, figure preparations, written description of the study in the form of manuscripts and/or progress reports.
• Contribute to research presentations at local, national, and international meetings.
• Oversight of laboratory technicians participating on the projects, including training them, and assisting them with experimental design and implementation.
• Compose and present sections of research reports.
• Organize and/or draft material for the preparation of research papers, manuscripts, or other documents for publication and/or presentation.

Qualifications:

Skills & Competencies

Required:

• The ideal candidate should have received (or expect to receive soon) a Ph.D. in a relevant biological field.
• First (or co-first) author of one or more peer-reviewed scientific publications
• Excellent English verbal and written communication skills
• Able to work both independently and in a team
• Experience with delivery of genomic therapies such as LNPs and/or genome editing - required.
• Experience in molecular genomic techniques (i.e., PCR, qPCR, RNAseq, gel electrophoresis)
• Experience in mammalian cell culture - required
• Interest in learning and troubleshooting new molecular biology techniques
• Familiarity with animal modeling of disease - required
• Excellent organizational and communication skills
• Sound interpersonal skills and the ability to supervise and train staff effectively.
• Ability to prioritize tasks, set deadlines, and adapt to shifting priorities in response to changing deadlines and needs of the lab.
• Ability to function with speed, precision, and an understanding of theory behind protocols and experiments.

Education:

Minimum

Required:

Doctoral Degree

Preferred:
Doctoral Degree

Experience:

Required:

Recent PhD graduate, 3+ years of experience in a research-related field required

Supervisory Responsibility (authority to hire, promote, or terminate):

May oversee research Assistants, Technicians, Technologists, and Students.

No authority to hire/promote/terminate

Working Conditions:

Work will be performed in the Simches Research Building on the Massachusetts General Hospital main campus, in Boston, MA.

Application Instructions:

Please do not apply through the Workday "Apply" button.

This position is being posted for informational purposes only. To be considered, please submit the following directly to the hiring manager by clicking the link below:

• CV/resume
• Cover letter

Remote Type:
Onsite

Work Location:

185 Cambridge Street

EEO Statement:

1300 Massachusetts General Physicians Organization, Inc. is an Equal Opportunity Employer. All qualified applicants will receive consideration for employment without regard to race, color, religious creed, national origin, sex, age, gender identity, disability, sexual orientation, military service, genetic information, and/or other status protected under law. We will ensure that all individuals with a disability are provided a reasonable accommodation to participate in the job application or interview process, to perform essential job functions, and to receive other benefits and privileges of employment.

To ensure reasonable accommodation for individuals protected by Section 503 of the Rehabilitation Act of 1973, the Vietnam Veteran's Readjustment Act of 1974, and Title I of the Americans with Disabilities Act of 1990, applicants who require accommodation in the job application process may contact Human Resources at .

At Mass General…