Associate Director, Quantitative Pharmacology and Pharmacometrics, Cardiometabolic

Responsibilities:

• Develop and apply model-based strategies (translational PK/PD, mechanistic models, population PK/PD, and clinical trial simulations) to support quantitative decision-making (dose selection, trial design, go/no-go).
• Represent QP2 on cardiometabolic discovery, early, and late clinical development teams using quantitative approaches.
• Partner with functional colleagues, external vendors, and strategic partners to build aligned, quantitative, model-informed approaches for drug discovery, development, and regulatory decisions.
• Collaborate across disciplines on study design, protocol development, execution, data interpretation, reporting, and results communication.
• Maintain knowledge of global regulatory expectations and contribute to regulatory document development and submission defense.
• Provide modeling input with pharmacometrics colleagues (strategies, analyses, interpretation, reporting).

• Ph.D. (4+ years), PharmD (6+ years), or MS (8+ years) in relevant field; increasing responsibility/independence in drug development, regulatory agency, or academia.
• Education in biopharmaceutics/pharmaceutical sciences/pharmacometrcs/chemical or biomedical engineering (or related quantitative discipline).
• Experience with population PK and PK/PD analyses using R, Matlab, Phoenix, NONMEM, Monolix, or similar tools.
• Strong written and verbal communication; ability to collaborate and plan complex work.
• Knowledge of modeling complex therapeutics and mechanistic modeling/QSP.

• Knowledge of cardiometabolic clinical drug development programs.
• Advanced math problem-solving, data analysis/interpretation, experimental design, and statistics.
• Understanding of biopharmaceutical/ADME properties of small molecules and/or biologics.
• Proven impact advancing decisions via model-based approaches.

• BI, Data Modeling, Data Science, Data Visualization, Machine Learning (ML), Software Development, Stakeholder Relationship Management, Waterfall Model.