Pharmacology Principal Research Associate

General Summary

The Pharmacology Principal Research Associate is responsible for delivering high-quality, independent research to evaluate the effects of compounds on ex vivo and/or in vivo disease biology. This individual demonstrates advanced technical proficiency, strong attention to detail, and the ability to troubleshoot and adapt methodological approaches. A key focus of this role is the design, execution, and analysis of flow cytometry and cell sorting experiments, particularly using ex vivo samples collected from rodent and large animal studies.

The ideal candidate will also have hands-on experience with basic in vivo techniques, including animal handling, dosing via multiple routes of administration (ROAs), perfusion, biofluid collection, tissue dissection/processing, and basic bioanalytical assays such as ELISA using serum and urine samples. While collaborating with their supervisor to set objectives, this individual maintains ownership of experimental design and execution.

• Design, execute, and interpret in vivo experiments with a high degree of independence and reliability
• Lead and support flow cytometry analysis and cell sorting workflows for ex vivo samples collected from rodent and large animal studies
• Perform sample/cell preparation, staining, acquisition, panel optimization, gating analysis, and sorting with strong technical rigor
• Apply sound judgment to prioritize studies based on project impact
• Conduct basic in vivo procedures, including:
  • Animal handling
  • Dosing through multiple routes of administration (ROAs)
  • Perfusion
  • Blood and other fluid sample collection
  • Tissue dissection and processing
• Perform basic analytical assays, including ELISA analysis of serum and urine samples
• Perform basic statistical analyses of experimental data, as appropriate
• Independently troubleshoot experimental challenges and refine protocols as needed
• Contribute to publication and patent submission processes
• Prepare clear, well-structured protocols, study plans, and reports
• Stay current with relevant scientific literature and emerging trends
• Present findings effectively at internal group, department, or project meetings
• Perform additional duties as assigned

• Strong technical expertise in flow cytometry analysis and cell sorting, including work with ex vivo samples from rodent and large animal tissues
• Demonstrated proficiency in designing and interpreting experiments to assess compound effects in ex vivo and/or in vivo disease models
• Hands‑on experience with basic in vivo pharmacology techniques, including animal handling, dosing via multiple ROAs, perfusion, fluid collection, and tissue dissection/processing
• Experience with basic analytical methods, including ELISA assays for serum and urine samples
• Solid understanding of core biological and immunological principles
• Ability to independently design, execute, and interpret follow‑up experiments
• Strong analytical skills, including interpretation of complex datasets and refinement of experimental protocols
• Proven reliability, particularly in high‑impact or sensitive studies
• Effective written and verbal communication skills within area(s) of expertise
• Developing knowledge of related scientific disciplines; background in muscular dystrophy and/or cystic kidney disease is a plus

• Bachelor's degree in a biological science required
• Typically requires:
  Bachelor's degree with 5+ years of experience, or Master's degree with 2+ years of experience

$89,800 - $134,800

The range provided is based on what we believe is a reasonable estimate for the base salary pay range for this job at the time of posting. This role is eligible for an annual bonus and annual equity awards. Some roles may also be eligible for overtime pay, in accordance with federal and state requirements. Actual base salary pay will be based on a number of factors, including skills, competencies, experience, and other job-related factors permitted by law.

At Vertex, our Total Rewards offerings also include inclusive market-leading benefits to meet our employees wherever they are in their career, financial, family and wellbeing journey while providing flexibility and resources to support their growth and aspirations. From medical, dental and vision benefits to generous paid time off (including a week-long company shutdown in the Summer and the Winter), educational assistance programs including student loan repayment, a generous commuting subsidy, matching charitable donations, 401(k) and so much more.

On-Site Designated

In this On-Site designated role, you will work five days per week on-site with ad hoc flexibility.

Note:

The Flex status for this position is subject to Vertex's Policy on Flex @ Vertex Program and may be changed at any time.

#LI-Onsite

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