Research Lab Tech

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The Brigham and Women's Hospital, Inc.

Mass General Brigham relies on a wide range of professionals, including doctors, nurses, business people, tech experts, researchers, and systems analysts to advance our mission. As a not-for-profit, we support patient care, research, teaching and community service, striving to provide exceptional care. We believe that high-performing teams drive groundbreaking medical discoveries.

A research lab within Brigham and Women's Cardiovascular Medicine division is looking for a highly motivated technical research assistant I. The lab uses both in vitro (human ESC/iPSC) and in vivo (zebrafish) techniques to model various cardiovascular disorders, including atrial fibrillation, hypertrophic cardiomyopathy, atherosclerosis, and arteriovenous malformations. By integrating transcriptional, (epi) genetic, metabolic, and phenotypic profiling at whole organism, issue, and single cell-level, the lab aims to understand the earliest molecular events characterizing disease onset, follow-up their dynamic changes over time, and to identify disease biomarkers.

The lab also uses these zebrafish models to expedite drug discovery in cardiovascular medicine.

A research lab within Brigham and Women's Cardiovascular Medicine division is looking for a highly motivated technical research assistant I. The lab uses both in vitro (human ESC/iPSC) and in vivo (zebrafish) techniques to model various cardiovascular disorders, including atrial fibrillation, hypertrophic cardiomyopathy, atherosclerosis, and arteriovenous malformations. By integrating transcriptional, (epi) genetic, metabolic, and phenotypic profiling at whole organism, issue, and single cell-level, the lab aims to understand the earliest molecular events characterizing disease onset, follow-up their dynamic changes over time, and to identify disease biomarkers.

The lab also uses these zebrafish models to expedite drug discovery in cardiovascular medicine.

• Perform a variety of laboratory experiments under general supervision. These will include molecular and cellular techniques such as PCR, microdissection, western blotting, immunofluorescence microscopy, DNA purification, and quantitative RT-PCR.
• Help to maintain zebrafish colonies.
• Preparation and maintenance of cell and tissue cultures .
• Preparation of laboratory reagents, chemicals, instruments, and equipment.
• Chemical informatics.
• Collaborate with a team of research assistants and post docs to meet project goals in a fast-paced and dynamic wet lab setting.
• Help to establish new and modify existing research techniques.
• Help to coordinate with core facilities and collaborating labs.
• Perform time-lapse microscopy and automated image processing.
• Meticulously record procedures and results in an electronic lab notebook; follow the required safe practices and comply with institutional policies and procedures.
• Discusses progress of work regularly with supervisors.
• May be asked to work some nights and weekends when needed (overtime will apply).
• All other duties, as assigned

Required:

• BA/BS in biology, chemistry, or closely related field
• 0-1 years experience

Preferred:

• Prior laboratory research experience.
• Prior experience working with zebrafish.

• Ability to perform a variety of laboratory experiments related to molecular and cellular biology.
• Exceptional ability to participate in team-based, high-throughput laboratory activities.
• Adaptability to changing experimental protocols and willingness to participate in setting up new protocols.
• Strong organizational skills, detail oriented.
• Ability to maintain an accurate and complete electronic lab notebook and electronic logs of stored samples.
• Knowledge of sterile techniques including ability to use pipettes, test tubes, culture dishes and flasks in a cell culture hood.
• Excellent analytical and communication skills.
• Interest in and willingness to accept new responsibilities.
• Ability to lift 20lbs.
• High personal standards for quality, accuracy, and completeness of experimental work

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