Senior Research Lab Tech, Mass Spectrometry, Nordmann Lab

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The General Hospital Corporation

Mass General Brigham relies on a wide range of professionals, including doctors, nurses, business people, tech experts, researchers, and systems analysts to advance our mission. As a not‑for‑profit, we support patient care, research, teaching, and community service, striving to provide exceptional care. We believe that high‑performing teams drive groundbreaking medical discoveries and invite all applicants to join us and experience what it means to be part of Mass General Brigham.

Summary

Join our team as a Sr. Research Lab Tech in the laboratory of Thierry Nordmann, MD, PhD. We are seeking a highly motivated, experienced, and detail‑oriented professional eager to contribute to groundbreaking research in inflammatory skin disease.

In this central role, you will run and maintain the laboratory's mass spectrometry platform and execute cutting‑edge workflows spanning human tissue processing, immunofluorescence imaging, laser microdissection, low‑input proteomic sample preparation, and ultra‑sensitive mass spectrometry.

As a member of a growing research group, you will work closely with postdoctoral and computational colleagues to generate high‑quality proteomic data on our state‑of‑the‑art Orbitrap Astral, and help establish the core methods and operational standards our group will build upon.

• Mass Spectrometry:
  Hands‑on operation, routine maintenance, and systematic troubleshooting of complex LC‑MS setups for high‑throughput quantitative proteomics. A minimum of 3 years of hands‑on LC‑MS experience is required. Prior experience with nanoflow workflows and modern instrument stacks (specifically the Orbitrap Astral, Vanquish Neo, and Evosep One) is highly desirable.
• Sample Preparation:
  Hands‑on expertise in protein extraction and enzymatic digestion, ideally including low‑input workflows and post‑translational modification (PTM) enrichments such as phosphoproteomics.
• Method Development:
  Optimizing and troubleshooting protocols and MS acquisition methods, and documenting them as rigorous laboratory SOPs.
• Tissue and Imaging:
  Practical experience with human tissue sectioning (cryosectioning and FFPE), immunofluorescence staining, or laser microdissection (LMD/LCM) is a strong advantage.

Develop or have input into modifications of existing assay techniques, experimental protocols, or new procedures.

• Synthesizes and interprets results.
• Prepares written and/or verbal status reports.
• Performs statistical analysis and makes recommendations.
• Independently performs non‑routine, highly specialized experimental procedures.
• Composes and may present sections of research reports and manuscripts.

Bachelor's Degree Related Field of Study required (Biochemistry, Analytical Chemistry, Molecular Biology, or a related field).

Experience in an academic or laboratory research setting 3-5 years required.

• Excellent communication skills.
• Good interpersonal skills and the ability to oversee the work of others.
• Ability to work independently.
• Ability to identify problems and develop solutions.
• Ability to prioritize tasks and set deadlines.
• Strong database management and overall computer skills.
• Functions with speed, precision and an understanding of theory behind tests and procedures.

Remote Type: Onsite

Work Location: 185 Cambridge Street

Scheduled Weekly

Hours:

40

Employee Type: Regular

Work Shift: Day (United States of America)

Pay Range: $50,502.40 - $82,014.40/Annual

Grade: 6

At Mass General Brigham, we believe in recognizing and rewarding the unique value each team member brings to our organization. Our approach to determining base pay is comprehensive, and any offer extended will take into account your skills, relevant experience if applicable, education, certifications and other essential factors. The base pay information provided offers an estimate based on the minimum job qualifications;

however, it does not encompass all elements contributing to your total compensation package. In addition to competitive base pay, we offer comprehensive benefits,…