Associate Scientist - Process Development

At Lilly, we unite caring with discovery to make life better for people around the world. We are a global healthcare leader headquartered in Indianapolis, Indiana. Our employees around the world work to discover and bring life-changing medicines to those who need them, improve the understanding and management of disease, and give back to our communities through philanthropy and volunteerism. We give our best effort to our work, and we put people first.

We’re looking for people who are determined to make life better for people around the world.

We are seeking a highly motivated Principal Engineer to join the Downstream Process Development team. The successful candidate will lead development and optimization of downstream purification processes supporting viral vectorprograms from research through preclinical development.

The ideal candidate will possess deep technical expertise in downstream purification technologies including ultracentrifugation, chromatography, and tangential flow filtration (TFF), with demonstrated experience driving process development strategies, platform development initiatives, technology implementation, and multi-functional collaboration.

This role requires strong scientific leadership, hands-on technical capability, and the ability to independently lead complex purification development activities in a fast-paced environment.

• Lead development, optimization, and scale-up of downstream purification workflows for viral vectors.
• Design and implement purification strategieusingng
  
  Iodixanol andCsCldensity gradient ultracentrifugation, affinity chromatography, ion-exchange chromatography (AEX/CEX), membrane chromatography, and polishing operations.
• Lead AKTA-based chromatography workflow development and process intensification initiatives.
• Develop scalable downstream platform approaches to support rapid material generation and process consistency across programs.
• Independently design experiments, analyze data, interpret results, and present technical conclusions to multi-functional teams and leadership.
• Drive troubleshooting, process characterization, and process robustness studies.
• Collaborate closely with upstream, analytical, manufacturing, and external partners to support program deliverables and timelines.
• Support technology transfer, process documentation, and development reports.
• Lead development and optimization of TFF/UFDF workflows for concentration, buffer exchange, formulation, and process scalability.
• Mentor junior scientists/engineers and provide technical guidance across purification activities.
• Contribute to implementation of new purification technologies, automation tools, and continuous process improvements.
• Ensure compliance with safety, documentation, and quality standards.

• Master’s degree in biology, biochemistry, chemical engineering, biotechnology or related field
• 8+ years of relevant downstream process development experience in industry
• Qualified applicants must be authorized to work in the United States on a full-time basis. Lilly will not provide support for or sponsor work authorization or visas for this role, including but not limited to F-1 CPT, F-1 OPT, F-1 STEM OPT, J-1, H-1B, TN, O-1, E-3, H-1B1, or L-1.

• CsCland iodixanol ultracentrifugation
• Affinity chromatography
• Ion-exchange chromatography
• TFF/UFDF operations including concentration, diafiltration, and formulation development
• AKTA systems and Unicorn software
• Strong understanding of process scale-up, platform development, and purification process characterization.
• Experience analyzing purification performance and product quality attributes using relevant analytical methods.
• Experience in AAV downstream process development and capsid enrichment workflows.
• Experience with automated chromatography systems and process intensification strategies.
• Experience supporting technology transfer and manufacturing readiness activities.
• Familiarity with GMP development environments and regulatory expectations.

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