Senior Scientist, siRNA therapeutics

Qilu Pharmaceuticals is a leading pharmaceutical and biopharmaceutical company in China, with 3 innovation centers in the US. We are seeking highly motivated and experienced scientists with strong assay development expertise to join our collaborative and fast-growing RNA Therapy team.

The successful candidate will play a key role in advancing innovative siRNA therapeutics for the treatment of serious diseases, including metabolic and liver diseases, neurological disorders, and ocular disease.

• sLead and execute preclinical screening and evaluation of siRNA candidates to support lead identification and candidate selection through integrated in vitro and in vivo studie
• sInvestigate target biology and mechanism of action; design and conduct proof-of-concept studies to validate therapeutic targets in collaboration with internal teams and external partner
• sDevelop, optimize, and implement cellular and biochemical assays to support drug discovery and preclinical research activitie
• sCollaborate closely with cross-functional teams, including chemistry, non-clinical development, bioinformatics, and external CRO partner
• sManage multiple projects and priorities simultaneously while delivering high-quality results within established timeline
• sDemonstrate scientific creativity, critical thinking, and a strong commitment to innovatio
• nMaintain compliance with applicable SOPs and laboratory standards; provide technical guidance and training to junior team members as neede
• dPresent scientific findings to project teams, leadership committees, and external collaborators. Communicate effectively across functions and organizational level

• cePh.D. in Molecular Biology, Pharmacology, Neuroscience, or a related discipline, with: 3+ years of industry experience in biotechnology or pharmaceutical research; or 5+ years of relevant postdoctoral experienc
• e.Experience working with siRNA, ASO, or other oligonucleotide therapeutics is highly preferr
• ed Extensive hands-on experience with RT-qPCR, ELISA, Western blotting, mammalian cell culture, animal handling, tissue collection, and tissue processing is requir
• ed Preferred technical skills include primary neuronal cell culture, stem-loop qPCR, and experience with rodent dosing techniques, including tail vein injection and intracranial administrati

• ns Demonstrated record of scientific achievement through high-quality publications, patents, or drug discovery contributio
• ns Strong experimental design, data analysis, and problem-solving skil
• ls Excellent organizational and project management abilities, with a proven ability to work independently and manage multiple prioriti
• es Thrives in a fast-paced, collaborative, and multidisciplinary research environmen
• t.Excellent verbal, written, and presentation skil