Principal Scientist, Discovery Separation Sciences

Job Description Position Overview

We are seeking an accomplished scientist and leader to join Discovery Chemistry as a Principal Scientist within the Boston Separation Sciences group.

The successful candidate will provide scientific leadership and operational oversight for purification and analytical chromatography capabilities supporting drug discovery programs across multiple modalities, including small molecules, peptides, targeted protein degraders, and emerging therapeutic formats. This role requires deep technical expertise in both HPLC and SFC chromatography and demonstrated experience supporting a broad range of purification workflows, including high-throughput library purification, singleton purification, chiral separations, and analytical support for medicinal chemistry programs.

The role combines laboratory leadership, scientific expertise, capability development, people management, and cross-functional collaboration to ensure the delivery of high-quality purification and analytical support to project teams.

The Principal Scientist will contribute to the advancement of Separation Sciences capabilities through the implementation of innovative technologies, development of scientific talent, optimization of workflows, and partnership with colleagues across Discovery Chemistry and adjacent functions. The individual will serve as a recognized subject matter expert while contributing to project, departmental, and capability strategies that enhance the effectiveness and impact of drug discovery efforts.

• Serve as a recognized subject matter expert in purification and separation sciences, providing scientific leadership and contributing to purification and analytical activities that enable Discovery Chemistry programs through the delivery of high-quality compounds, analytical data, and scientific recommendations.

• Provide technical leadership and expertise in chromatographic purification, analytical separations, impurity isolation, and related technologies, while guiding resolution of complex scientific and operational challenges.

• Foster a culture of scientific excellence, operational efficiency, safety, and quality throughout laboratory operations.

• Champion and implement innovative technologies, laboratory informatics platforms, LIMS solutions, automation-enabled purification workflows, and digital capabilities that enhance the effectiveness, efficiency, and impact of Separation Sciences capabilities.

• Establish best practices, drive continuous improvement initiatives, and contribute to capability roadmaps aligned with Discovery Chemistry priorities.

• Recruit, manage, mentor, and develop scientists and laboratory staff, building both technical expertise and leadership capability across the organization.

• Foster a collaborative, inclusive, and high-performing environment that supports employee development, succession planning, and scientific excellence.

• Partner closely with Medicinal Chemistry, Process Chemistry, Analytical Sciences, Automation, Informatics, IT, and other research functions to support project progression and capability development.

• Serve as a trusted scientific partner to project teams, contributing purification and analytical expertise to project strategy and departmental initiatives.

• Partner in laboratory operations, instrumentation strategy, capital planning, and implementation of automation and digital solutions that improve scientific productivity.

• Partner with Facilities, Procurement, Engineering, IT, and external vendors to ensure…