Associate Scientist II, Biology

Overview

The Research Department at Alnylam is seeking a highly motivated Associate Scientist II to join our innovative Next Wave, Target Discovery and Validation team. Our mission is to discover novel genetically informed targets and experimentally validate them to build a strong foundation for future RNAi-based therapeutics.

The Research Department at Alnylam is seeking a highly motivated Associate Scientist II to join our innovative Next Wave, Target Discovery and Validation team. Our mission is to discover novel genetically informed targets and experimentally validate them to build a strong foundation for future RNAi-based therapeutics.

This role offers an opportunity to work across a variety of disease areas and build the scientific and experimental biology data package to support the discovery of the next generation of RNAi therapeutics and positively impact patients’ lives. The successful candidate will generate high quality in vitro and in vivo data in a collaborative, cross‑functional research environment to support a target’s nomination from ideation into the drug discovery pipeline.

Responsibilities will include developing and executing in vitro cell-based assays, executing studies in in vivo rodent disease models, conducting a variety of molecular biology techniques for transcript and protein quantification, and analyzing, interpreting, and communicating the associated data. A collaborative team mindset, passion and curiosity for science, and a desire to learn new techniques are a must. This position is lab based and on site
, located in Cambridge, MA.

• Design, develop, and execute studies to evaluate targets for nomination into RNAi therapeutic discovery programs
• Collaborate closely with other members of cross‑functional teams and under the guidance of project leads to ensure project goals are met
• Design, develop, and execute molecular biology assays, in vitro cell‑based assays, and in vivo procedures in rodents
• Analyze, document, and interpret experimental data with strong attention to detail and data integrity
• Present and communicate results with key stakeholders within teams and across the organization

• Bachelors in a scientific discipline with 1‑3 years of relevant laboratory experience or Master degree with 1 year of relevant laboratory experience.
• Industry experience is preferred but not required
• Experience with standard molecular biology techniques is required
• Experience with in vitro cell culture and/or in vivo rodent skills is preferred but not required
• Ability to perform and troubleshoot assays using knowledge of experimental design and underlying scientific principles
• Ability to analyze results, propose future directions, and generate clear reports
• Must be flexible, embrace new tasks and challenges, and able to work on tight deadlines
• Ability to work in a team environment

We are the leader in RNAi therapeutics- a revolutionary approach with the potential to transform the lives of people with rare and common diseases. Built on Nobel Prize-winning science, Alnylam has delivered the breakthroughs that made RNAi therapeutics possible and are just at the beginning of what’s possible. Our deep pipeline, late‑stage programs, and bold vision reflect our core values: fierce innovation, passion for excellence, purposeful urgency, open culture and commitment to people.

We're proud to be a globally recognized top employer, wherean authentic, inclusive culture and breakthrough thinking fuel one another. At Alnylam, we commit to an inclusive recruitment process and equal employment opportunity. Qualified applicants will receive consideration for employment without regard to their sex, gender or gender identity, sexual…