Research Associate Scientist, In vivo Oncology Drug Discovery Unit - Takeda

Research Associate Scientist, In vivo Oncology Drug Discovery Unit - Takeda About the role:

The Oncology Drug Discovery Unit (ODDU) is looking for an Associate Scientist to join a collaborative and dynamic team. You will oversee the discovery and development of novel therapeutics supporting new and ongoing pipeline programs in the ODDU. This is a lab-based role and you will work with the in vivo lead and and be responsible for critical path activities with demonstrated in vivo skills in immuno-oncology drug discovery or translational sciences.

You should have a foundation in in vivo models specifically related in vivo and ex vivo pre-clinical models of cancer. As an important member of the team, you will be responsible for new model development, cell line characterization, target validation, assessing therapeutic concepts of several immune engager molecules and advancing development candidates to IND. You will collaborate with important partners, including those in the ODDU and those in partnering organizations (Global Biologics, DSRE, DMPK, and Translational Oncology).

Develop animal models to test the biological efficacy of therapeutic agents for oncology indications

Design and implement in vivo efficacy models in xenograft and PDX models

Participate in analysis of in vivo studies to help establish PK / PD / efficacy relationships.

Help with external collaborations with CROs and and establish new protocols

Execute experiments with minimal supervision and deliver comprehensive high quality data sets to help decision-making

Identify experimental protocols and in vivo models

Identify, plan, and execute well defined scientific projects and communicates program strategy and timelines to management.

Interpret results of complex experiments

Prepare and present comprehensive technical or project reports and formal presentations

Maintain laboratory notebooks and follow laboratory practices in compliance

MS in a scientific discipline (or equivalent) with 3+ years relevant industry experience, or BS in a scientific discipline with 5+ years experience, or Associates degree in scientific discipline with 7+ years relevant industry experience

Proficiency with in vivo efficacy rodent models, including mouse syngeneic, xenograft and PDX models

Experimental skills, including mammalian tissue culture, in vivo model development, drug administration by multiple routes (IV, SQ, IP, IT, PO), and blood/tissue collection. Imaging experience is highly desirable.

Experience culturing and maintaining human tumor cell lines and primary human cells, preferably T cells, with best practices in tissue culture is important.

Knowledge in immunology or immune oncology. Understanding of cell and gene therapies.

Experience with biologics is prefered (Antibodies, ADCs, Cell therapeis etc)

Hands –on basic experience with multi-color flow cytometry, molecular biology techniques (PCR, Gibson assembly, cloning etc), ELISA, MSD and other standard cell-based and non-cell based biochemical assays.

Experience in molecular biology and biochemical techniques such as western blot, molecular cloning is a plus.

Use of scientific databases and application for data management and data analysis (Graph Pad Prism, Soft Max Pro, Office 365, Flow Jo etc)

Comprehensive Healthcare:
Medical, Dental, and Vision

Financial Planning & Stability: 401(k) with company match and Annual Retirement Contribution Plan

Health & Wellness programs including onsite flu shots and health screenings

Generous time off for vacation and the option to purchase additional vacation days

Community Outreach Programs and company match of charitable contributions

Family Planning Support

Flexible Work Paths