Director, Nonclinical Development - ADME​/DMPK

Rhythm is a global, commercial-stage biopharmaceutical company committed to transforming the lives of patients living with rare neuroendocrine diseases. We develop medicines for previously untreatable or undertreated diseases. We recognize the courage it takes for patients and their caregivers to begin their journey of advocacy to find the answers they need. Their courage inspires us to challenge convention, ask bold questions and seek answers for them.

Every day, we strive for excellence through our willingness to adapt, learn, and our tenacity to overcome barriers, together.

We are seeking an experienced Director of Nonclinical Development, ADME/DMPK to provide strategic scientific leadership and execution of drug metabolism and pharmacokinetics (DMPK) strategies across our portfolio. This individual will serve as the ADME/DMPK subject matter expert and will be accountable for driving integrated, cross‑functional nonclinical development strategies and work streams supporting small molecule and peptide therapeutics from IND‑enabling development through late‑stage clinical development and registration.

The Director will play a critical role in understanding and predicting drug disposition, exposure‑response relationships, metabolite characterization, drug‑drug interaction risk, and translational science, including the application of PBPK and other modeling approaches. This individual will lead the nonclinical inputs to first‑in‑human dose selection and dose escalation strategy and will serve as a key scientific voice in internal first‑in‑human and dose‑selection reviews.

Success in this role requires strong scientific judgment, the ability to operate comfortably in a fast‑paced environment, and the confidence to contribute an independent scientific perspective in a collaborative and constructive manner. This individual will be an independent self‑starter who thrives in a highly collaborative cross‑functional team environment.

This is a highly visible role that requires an exceptional scientific communicator. The Director will be expected to distill complex scientific and technical information into clear, actionable messages and to communicate strategic priorities, data interpretation, and risk cross‑functionally and to senior leadership with clarity and confidence. This is an individual contributor role with significant cross‑functional leadership scope; the Director will lead through influence across program teams rather than through direct reports.

This role will contribute to portfolio‑level decision making, development prioritization, and governance discussions by providing expert scientific assessment of program opportunities, development risks, and translational strategies across the pipeline.

• Own and drive integrated ADME/DMPK strategies supporting programs from candidate selection and IND‑enabling development through Phase 2/3 development, registration, and life‑cycle management.
• Partner with Discovery and Medicinal Chemistry teams to evaluate develop ability, optimize candidate properties, and inform candi
• Serve as the DMPK representative and strategic Nonclinical Development partner on cross‑functional program teams, contributing to program strategy, risk assessment, translational planning, and key development decisions.
• Accountable for the planning, prioritization, and delivery of cross‑functional Nonclinical Development work streams, including timelines, budgets, and interdependencies with Clinical, Regulatory, CMC, and other functions.
• Lead the nonclinical PK/PD and exposure‑based analyses that underpin first‑in‑human starting dose selection, dose escalation design, and exposure caps, including NOAEL‑ and MABEL‑based…