Analytical Principal Research Scientist

** Job Description
**** General

Summary:

** Vertex Pharmaceuticals is seeking a highly motivated and dynamic
** Principal Research Scientist
** to join our Dissolution Team within the Formulation Development Department.

This role offers a unique opportunity for a driven individual to contribute to the advancement of our scientific capabilities while growing into a leader within the team. The ideal candidate will possess a strong scientific foundation, a passion for learning, and the ability to lead with a sense of urgency and purpose.

As a key member of the Dissolution Team, this individual will play a pivotal role in supporting our drug development efforts, driving innovation, and fostering a collaborative and high-performing team culture. While prior experience in dissolution is beneficial, we are seeking a candidate who demonstrates exceptional leadership potential, a commitment to continuous learning, and the ability to thrive in a fast-paced, dynamic environment.
** Key

Duties and Responsibilities:

**
* ** Leadership and Team Development**:  + Lead by example, fostering a culture of collaboration, innovation, and excellence within the Dissolution Team  + Mentor and guide team members, supporting their professional growth and development  + Actively contribute to creating a positive, inclusive, and high-performing team environment that aligns with Vertex’s core values
* ** Scientific Contributions**:  + Collaborate with cross-functional teams to design, execute, and interpret dissolution studies to support formulation development and regulatory submissions  + Justification of clinically relevant dissolution method parameters and specifications  + Understanding of key analytical deliverables for late-stage programs including method development, validation, specification setting, stability, release testing and analytical strategies to bring these individual items together collectively for a fast-paced program  + Authoring dissolution sections for regulatory submissions  + Designing validation protocols that are in compliance with ICH and FDA guidelines  + Identifying critical factors/parameters that may not be mandated by guidelines but are essential for developing a robust method and validating it for its intended use
* ** Problem Solving and Decision Making**:  + Approach challenges with a solution-oriented mindset, leveraging critical thinking and scientific expertise to address complex problems  + Engage in constructive debates and discussions to drive data-driven decision-making and achieve optimal outcomes
* ** Continuous Learning and Growth**:  + Stay abreast of emerging trends, technologies, and best practices in dissolution science and analytical chemistry  + Proactively seek opportunities for professional development and apply new knowledge to enhance team capabilities  + Demonstrate a commitment to lifelong learning and personal growth, with a focus on developing leadership skills
* ** Operational Excellence**:  + Work with a sense of urgency to meet project timelines and deliver high-quality results  + Ensure compliance with regulatory guidelines and company policies in all aspects of dissolution testing and reporting  + Contribute to the development and implementation of standard operating procedures (SOPs) and best practices
** Knowledge and

Skills:

*** Demonstrated ability to develop solutions to complex problems with creativity and innovation
* Proven teamwork, leadership and collaboration skills, with a demonstrated ability to interact with and influence diverse audiences
* Excellent teamwork, verbal and written communication skills
*
* Education and Experience:

*** Ph.D. degree in Chemistry, Chemical Engineering or Pharmaceutical Chemistry and 4-7 years experience, or Master’s and 7+ years experience, or Bachelor’s and 10+ years experience
* Demonstrated ability to learn and apply new scientific concepts and techniques
* Strong interpersonal and communication skills, with the ability to foster collaboration and build relationships across teams
* Proven ability to lead, mentor, and inspire team members, with a desire to grow into a managerial role
* A passion for innovation, problem-solving,…