Principal Scientist, Discovery Oncology

Principal Scientist – Oncology Drug Discovery

We are seeking a highly qualified and motivated Principal Scientist with a strong background in oncology drug discovery to join our Discovery Oncology team in Boston. The successful candidate will have a track record of innovative and collaborative oncology research and drug discovery, and experience managing other scientists. In this role you will lead the conception, design, and execution of discovery-stage research programs and partner closely with cross‑functional teams across the organization to advance differentiated cancer therapies from target selection through early development.

You will also manage and support lab-based direct reports in designing and executing experiments to progress discovery programs.

• Lead discovery efforts to deliver differentiated oncology programs through effective cross‑functional collaboration with stakeholders across the organization.
• Analyze the evolving oncology treatment landscape to identify gaps, unmet medical needs, and competitive opportunities.
• Effectively manage and lead multiple projects, design experiments, manage resources, analyze, interpret, and present data.
• Manage multiple direct reports: provide scientific and technical leadership to a small, high‑performing team, driving innovation, quality, and excellence in experimental design and data interpretation; foster talent growth and development.
• Foster a high‑performance culture of collaboration, engagement, and inclusion. Establish strong relationships within highly collaborative, multidisciplinary teams to effectively drive drug discovery initiatives.

Education:

• Bachelor’s (with 14+ years of experience) or Master’s (with 10+ years) or Ph.D. (with 8+ years) in cell and molecular biology, cancer biology, or related field and relevant experience.

Required

Experience and Skills:

• Deep expertise in tumor biology, including cancer genomics and oncogenic signaling.
• Extensive experience leading drug discovery programs.
• Broad technical expertise in molecular and cellular biology, biochemistry, and analytical methods.
• Experience managing scientists and demonstrated ability to manage multiple projects concurrently.
• Demonstrated ability to drive innovative research, evidenced by high‑impact publications, patents, and/or successful advancement of discovery programs.
• Strong team player with excellent communication skills and ability to work collaboratively and thrive in a team environment.
• Proven record of innovative thinking to propose and champion new ideas and solve problems.

Preferred

Experience and Skills:

• Hands‑on experience with a broad range of therapeutic modalities.
• Experience in small molecule inhibitors and novel use of small molecules, including induced proximity.

Salary range: $ – $. The successful candidate will be eligible for annual bonus and long‑term incentive, if applicable. We offer a comprehensive package of benefits, including medical, dental, vision, and other insurance benefits for employee and family, retirement benefits including 401(k), paid holidays, vacation, and compassionate and sick days.

US and Puerto Rico residents only. San Francisco residents only: we will consider qualified applicants with arrest and conviction records for employment in compliance with the San Francisco Fair Chance Ordinance. Los Angeles residents only: we will consider for employment all qualified applicants, including those with criminal histories, consistent with local laws.

As an Equal Employment Opportunity Employer, we provide equal opportunities to all employees and applicants for employment and prohibit discrimination on the basis of race, color, age, religion, sex, sexual orientation, gender identity, national origin, protected veteran status, disability status, or other applicable legally protected characteristics. We are a federal contractor and comply with affirmative action requirements for protected veterans and individuals with disabilities.