Sr Associate Scientist

Sr Associate Scientist - Contract - Boston, MA

Drive the chemistry behind next-generation immuno-oncology therapies.

Proclinical is seeking a Sr Associate Scientist to join a dynamic team in Boston, MA. The position offers an exciting opportunity to contribute to cutting-edge work in the immuno-oncology and pharmaceutical space.

Primary Responsibilities:

The successful candidate will focus on hands-on laboratory support and process development for the chemical synthesis and downstream processing of oligonucleotide-based drug substances.

Skills & Requirements:

• A degree in Chemistry or a related field with relevant laboratory experience, preferably in an industrial setting.
• Basic understanding of analytical techniques such as pH, osmolality, conductivity measurement, HPLC, and LC-MS.
• Hands-on experience with oligonucleotide manufacturing processes, including phosphoramidite chemistry, chromatography, and ultrafiltration, is a plus.
• Strong commitment to maintaining high laboratory and scientific standards.
• Excellent communication skills and the ability to work collaboratively in a fast-paced, team-oriented environment.
• Proactive and responsible approach to work, with the ability to meet aggressive timelines.

The Sr Associate Scientist's responsibilities will be:

• Perform chemical synthesis of oligonucleotides at scales up to 11 mmol.
• Conduct downstream processing of oligonucleotides, including preparative HPLC, ultrafiltration, annealing, concentration, and lyophilization.
• Carry out in-process analytical testing using techniques such as AX-HPLC, IPRP-HPLC, LC-MS, and UV-vis.
• Provide technical support for optimizing contract manufacturing processes.
• Maintain a safe, clean, and organized laboratory environment, assisting with routine lab and equipment maintenance.
• Ensure accurate record-keeping and adherence to excellent laboratory documentation practices.

If you are having difficulty in applying or if you have any questions, please contact Mike Raletz at

If you are interested in applying to this exciting opportunity, then please click 'Apply' or to speak to one of our specialists please request a call back at the top of this page.

Proclinical is a leading life sciences recruiter focused on finding exceptional people and matching them with the finest positions across the globe. Proclinical is acting as an Employment Agency in relation to this vacancy.

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