Clinical Development Medical Director Vertex Pharmaceuticals in Boston, MA

General Summary

The Clinical Development Medical Director will serve as the Medical Lead for Vertex clinical trials, working with cross‑functional multidisciplinary study teams on clinical trial strategy, design and execution and serving as the Medical Monitor responsible for monitoring the safety of enrolled subjects on assigned trials. The incumbent will work on multiple trials in all phases of clinical development and may also participate in other selected projects in clinical development.

• Leads the development of study protocols, investigator brochures, clinical development plans and other key study documents in conjunction with other line functions and with minimal guidance.
• Serves on cross‑functional study execution teams for assigned trials, working with other team members to achieve efficient, high‑quality study execution.
• Participates in the preparation of regulatory documents in support of regulatory submissions, including clinical sections of INDs and CTAs, safety reports and annual reports for assigned trials, responses to regulatory authorities and ethics committees/IRBs, and other documents as appropriate.
• Provides scientific and clinical input to study‑related documents and analysis plans including informed consent forms (ICF), clinical research forms (CRF), statistical analysis plans (SAP), clinical pharmacology analysis plans (CPAP), and clinical study reports (CSR). Acts as liaison between translational medicine/clinical development and other internal groups at Vertex for assigned studies.
• Represents Vertex to outside medical personnel in the development of clinical protocols and study conduct.
• Performs other duties as assigned related to clinical programs.

• Excellent oral and written communication skills.
• Ability to work collaboratively in a fast‑paced, team‑based, matrix environment and to function independently as appropriate.
• Effectiveness at building alliances across functions, based on end‑to‑end drug development thinking and experience.
• Board certification/eligibility in a medical, pediatric or surgical subspecialty.

• MD, DO or equivalent ex‑US medical degree.
• Board certification/eligibility in a specialty field is highly desired.
• Typically requires 10 years of basic or clinical research experience in an academic or industrial setting, or the equivalent combination of education and experience.
• Typically requires experience in analysis of research data and publications; working knowledge of biostatistics; working knowledge of GCP, scientific and clinical research methods and clinical study design.
• Typically requires experience with design, execution, and analysis of clinical trials required.

Pay Range: $240,000 - $360,000

Disclosure Statement:
The range provided is based on what we believe is a reasonable estimate for the base salary pay range for this job at the time of posting. This role is eligible for an annual bonus and annual equity awards. Some roles may also be eligible for overtime pay, in accordance with federal and state requirements. Actual base salary pay will be based on a number of factors, including skills, competencies, experience, and other job‑related factors permitted by law.

Flex Designation:
Hybrid‑Eligible Or On‑Site Eligible

Vertex is committed to equal employment opportunity and non‑discrimination for all employees and qualified applicants without regard to a person's race, color, sex, gender identity or expression, age, religion, national origin, ancestry, ethnicity, disability, veteran status, genetic information, sexual orientation, marital status, or any characteristic protected under applicable law. Vertex is an E‑Verify Employer in the United States. Vertex will make reasonable accommodations for qualified individuals with known disabilities, in accordance with applicable law.

Any applicant requiring an accommodation in connection with the hiring process and/or to perform the essential functions of the position for which the applicant has applied should make a request to the recruiter or hiring manager, or contact Talent Acquisition at A