Director, Discovery Oncology, Molecules

Job Summary

Discovery Oncology is seeking a visionary and driven people leader to discover and advance the next generation of small molecule oncology therapeutics. The successful candidate will lead a team at our Boston site focused on small molecule therapeutics, with opportunities to contribute across additional modalities and partner across the organization to shape Discovery Oncology strategy and advance our growing pipeline.

• Design and execute the future of our company's oncology therapeutics, particularly small molecules.
• Lead the employment of small molecules to create effective, tolerable, combinable medicines that are both first‑in‑class and best‑in‑class.
• Leverage deep understanding of cancer biology and the current oncology landscape to drive therapeutic opportunity decisions.
• Deliver milestones key to pipeline advancement, such as preclinical candidates and IND filings for first‑in‑human studies.
• Serve as an experienced program lead and mentor others to become strong program leaders.
• Contribute expertise and vision to business‑development evaluations of molecules or platforms of interest.
• Contribute to the development and execution of strategy and the growth and development of staff as a member of the Discovery Oncology Leadership team.
• Foster a high‑performance culture of collaboration, engagement, self‑accountability, and inclusion.

• Ph.D. in Biology, Immunology, Biochemistry, Pharmacology, Toxicology, Bioengineering, Biotechnology, Oncology, Biophysics, Biologics, or a related STEM field with 8+ years of post‑degree experience in industry or equivalent OR MS with 10+ years of experience.
• Extensive background in cancer biology, including intrinsic pathways and key cancer drivers.
• Evidence of innovative approaches to small molecule design, particularly induced proximity.
• Proven track record of advancing well‑designed investigative new small molecule drugs into the clinic with a focus on patient experience and successful clinical execution.
• Clear experience in late program leadership partnering with regulatory, translational sciences and clinical development to initiate and advance investigative drugs and experience writing IND modules.
• Experience managing a group of senior and junior scientists with a track record of achievements, including project leadership and strategic contributions.
• Ability to build strong relationships within highly collaborative, multidisciplinary teams to effectively drive drug discovery initiatives.
• Excellent attention to detail and strong oral and written communication skills.
• Highly self‑motivated and capable of prioritizing deliverables among multiple projects.

• Large breadth of small molecule experience, including novel approaches.
• Experience with modalities beyond small molecules is beneficial, particularly including small molecule payloads.

Salary range: $ - $. The successful candidate will be eligible for an annual bonus and long‑term incentive, if applicable. We offer a comprehensive package of benefits, including medical, dental, vision, retirement benefits (401(k)), paid holidays, vacation, and compassionate and sick days. For more information about benefits, visit

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