Sr. Principal Scientist, Clinical Operations Immunology Lead

Job Description

Translational Medicine (TMed) drives early clinical development of novel therapeutics by partnering with Discovery Sciences and Late-Stage Clinical Research to translate scientific discoveries into human proof-of-concept and advance the most promising candidates through the pipeline to patients. Our Clinical and Operations organization designs and executes clinical pharmacology strategies spanning first-in-human studies through proof-of-biology/proof-of-concept and into late-stage development, supporting worldwide marketing applications and lifecycle management.

Take a clinical operations leadership role at the intersection of discovery and clinical development to advance novel immunology therapeutics from bench to bedside. Influence strategy, build teams, and deliver high-impact clinical programs that shape the future of patient care.

• Co‑own and execute the early clinical development strategy for the immunology portfolio with the Head of TMed Immunology
• Provide comprehensive strategic planning and operational oversight for immunology clinical programs and trials to maximize operational feasibility, efficiency, and ensure consistency and quality across the portfolio
• Build global network of immunology sites and foster relationships with key investigators for Phase 1b/2a patient trials to deliver on clinical program goals
• Serve as the deep subject‑matter expert and issue escalation point for early immunology clinical operations
• Ensure appropriate resources, competencies, and partnerships are in place to meet objectives
• Critically review strategy and clinical program documents (development plans, investigator’s brochures, protocols, etc.), providing scientific and operational insight to ensure the best path forward
• Partner with Business Development and Licensing to evaluate internal and external opportunities that align with portfolio strategy
• Actively participate in annual and quarterly planning cycles: identify risks, develop and execute mitigation plans, and track performance metrics and outcomes
• Ensure immunology data integrity across the organization (Book of Business, CTMS, etc.)
• Build and sustain strong cross‑functional relationships (country operations, clinical supplies, data management, regulatory, etc.) across departments, divisions, and geographies
• Foster the people pipeline: attract, coach, mentor, and retain talent; provide performance‑management support; act as a “player‑coach” to enrich group skillsets. Potential for people management
• Represent TMed on enterprise strategic initiatives and lead continuous‑improvement efforts that increase clinical efficiency and scientific impact
• Serve as a member of the TMed Clinical Operations leadership team and contribute to shaping department strategy

• Degree in Life Sciences with one of the following experience combinations:
  Bachelor’s degree + ≥16 years related experience, master’s degree + ≥15 years related experience, or PhD/PharmD + ≥12 years related experience

• Pharmaceutical industry roles in clinical drug development, clinical trial management, clinical site monitoring/training, medical/regulatory writing, or translational science

• Extensive clinical operations experience in the planning and execution of early clinical development trials (Phase1 and early proof‑of‑concept)
• Demonstrated ability to translate knowledge to other areas to effectively collaborate, network, and influence peers, senior leaders, and external partners
• Proven track record building and leading high‑performing cross‑functional teams in a matrixed environment
• Strong decision‑making skills, weighing advantages, disadvantages, and business impact for rapid decisions and proven track record delivering results on firm deadlines
• Ability to work successfully with ambiguity and embrace uncertainty
• Strong oral and written communication skills
• Experience attracting, developing, and retaining talent

• Experience leading clinical programs and trials for gastroenterology, dermatology, and/or rheumatology, especially autoimmune or immune‑mediated disorders,…