Scientific Software Developer II – Modeler

Open Eye, Cadence Molecular Sciences is seeking a Computational Chemist/Cheminformatician to join our team of experts in mathematics, computational modeling, and medicinal chemistry.

This role will require interactions with customers and Open Eye’s scientific and technical teams.

• Extend Open Eye’s programming toolkits by developing and implementing new and useful scientific and technical features to aid customers in developing bespoke solutions.
• Explore methods for further enhancing Open Eye’s virtual screening platform (including OMEGA, ROCS, FastROCS, ROCS X, OEDocking).
• Apply chemistry/cheminformatics expertise with ML experts to build robust, scalable models to support data‑driven decision making.
• Work on retrospective and prospective projects both internally and with collaborators to validate methodologies.
• Work with the Orion project team to further optimize compound design workflows in Orion.

• PhD (or equivalent experience) in computational chemistry, chemistry, cheminformatics, or a related field with 0–3 years relevant experience.
• Knowledge of traditional computational chemistry approaches such as docking, virtual screening, molecular modeling, etc.
• Programming expertise, ideally in C++ and/or Python, preferably with experience using AI coding agents.
• Experience in or desire to learn about the pharmaceutical industry.
• Strong desire to find practical solutions to challenging problems.
• Demonstrated ability to work both as part of a team and independently.
• Experience with Open Eye software/toolkits (plus).
• Experience with synthetically accessible, pharmaceutically relevant generative chemistry (plus).

The annual salary range for Massachusetts is $101,500 to $188,500. You may also be eligible to receive incentive compensation: bonus, equity, and benefits.

Our benefits programs include: paid vacation and paid holidays, 401(k) plan with employer match, employee stock purchase plan, a variety of medical, dental and vision plan options, and more.