Principal Scientist; Director), Anatomic Pathologist

Job Description

Translational Molecular Biomarkers (TMB) is responsible for translating preclinical molecular biomarkers to clinical development across all therapeutic areas and all phases of clinical development at our company's Research Laboratories. TMB laboratories leverage a variety of technologies to develop biomarker assays that confirm engagement of therapeutic targets and help understand mechanisms of drug action and patient response.

• Establish new histopathology‑based assays in the laboratory as part of a team.
• Provide thorough histopathological reviews and test clinical samples, leveraging expertise in disease processes and pathways targeted by our therapeutics.
• Collaborate in the development and analytic validation of digital pathology algorithms.
• Interface with scientists and physicians in early and late‑stage clinical development to execute histopathology‑based biomarker strategies in clinical trials.
• Provide subject‑matter expert pathologist input in a highly matrixed environment, collaborating with internal and external stakeholders.

• Doctor of Medicine (MD or equivalent) or MD/PhD with specialized training in Anatomic Pathology.

• Post‑residency training experience of 1‑3 years, including biological research and multidisciplinary teamwork.
• Proficient in general anatomic pathology diagnosis and routine histopathology testing, including immunohistochemistry (IHC), cytogenetics (in-situ hybridization), sample quality and testing procedures, and applicable laboratory testing regulations.
• Excellent oral and written communication skills with a proven record of scientific contributions.
• Demonstrated ability to lead and manage projects in a fast‑paced environment.
• Ability to interact well with groups and maintain strong working relationships with internal and external collaborators.
• Strong understanding of clinical laboratory regulatory standards and GxP compliant workflows.
• Strong understanding of disease processes and pathways relevant to our therapeutics.

• Experience with development and analytic validation of digital or computational pathology algorithms.
• Experience working in the diagnostic or pharmaceutical industry.
• Broad knowledge of the drug development process and translational medicine.
• Experience in clinical biomarker development or managing the implementation of biomarker assays in support of drug development.
• Experience with multiplex tissue‑based spatial profiling assays (e.g., multiplex immunofluorescence, multiplex chromogenic immunohistochemistry, imaging mass cytometry, spatial transcriptomics).
• Familiarity with clinical‑grade whole slide imaging platforms (e.g., Leica Aperio, Hamamatsu, Roche DP 600).
• Proficiency in commercial or open‑source image analysis software packages (e.g., Visiopharm, HALO, QuPath).
• Knowledge of statistical software packages (e.g., Prism, SPSS).
• Understanding of regulated clinical bioanalysis.

Anatomic Pathology, Biomarkers, Clinical Judgment, Clinical Research, Cross‑Functional Teamwork, Digital Pathology, Drug Development, Histopathology, Immunochemistry, Immunohistochemistry (IHC), Laboratory Research, Pathology, Translational Medicine

Salary range: $ – $. Successful candidates will be eligible for annual bonus and long‑term incentive, if applicable.

Comprehensive benefits package including medical, dental, vision, health care, retirement benefits (401(k)), paid holidays, vacation, compassionate and sick days. More information available at our benefits website.

As an Equal Employment Opportunity Employer, we provide equal opportunities to all employees and applicants for employment and prohibit discrimination on the basis of race, color, age, religion, sex, sexual orientation, gender identity, national origin, protected veteran status, disability status, or other applicable legally protected characteristics. As a federal contractor, we comply with all affirmative action requirements for protected veterans and individuals with disabilities.

For more information about personal rights under the U.S. Equal Opportunity Employment laws, visit EEOC Know Your Rights and EEOC GINA Supplement.

Final date to receive applications is stated on the posting. This position is open to U.S. and Puerto Rico residents only, with specific residency requirements for San Francisco and Los Angeles. The position offers a hybrid work arrangement and requires up to 10% travel.