Principal Scientist; Director), Anatomic Pathologist

Overview

Translational Molecular Biomarkers (TMB) is responsible for translating preclinical molecular biomarkers to clinical development across all therapeutic areas and all phases of clinical development. TMB laboratories leverage a range of technologies to develop biomarker assays that confirm therapeutic target engagement and illuminate mechanisms of drug action and patient response.

• Establish new histopathology-based assays in the laboratory as part of a team.
• Provide thorough histopathological reviews and test clinical samples, utilizing expertise in disease processes and pathways targeted by the company’s therapeutics.
• Collaborate in the development and analytic validation of digital pathology algorithms.
• Interface with scientists and physicians in early and late‑stage clinical development to execute histopathology‑based biomarker strategies in clinical trials.
• Offer subject‑matter expert pathologist input in a matrixed environment, collaborating with internal and external stakeholders.

• Doctor of Medicine (MD) or MD/PhD with specialized training in Anatomic Pathology.

• Post‑residency training experience of 1-3 years, including experience in biological research and ability to work effectively in multidisciplinary teams.
• Proficiency in general anatomic pathology diagnosis and routine histopathology testing, including immunohistochemistry (IHC), cytogenetics (in‑situ hybridization), sample quality and testing procedures, and applicable laboratory testing regulations.
• Excellent oral and written communication skills with a proven record of scientific contributions.
• Demonstrated ability to lead and manage projects in a fast‑paced environment.
• Ability to interact well with groups and maintain strong working relationships with internal and external collaborators.
• Strong understanding of clinical laboratory regulatory standards and GxP compliant workflows.
• Strong understanding of disease processes and pathways relevant to the company’s therapeutics.

• Experience with the development and analytic validation of digital or computational pathology algorithms.
• Experience working in the diagnostic or pharmaceutical industry.
• Broad knowledge of the drug development process and translational medicine.
• Experience in clinical biomarker development or managing the implementation of biomarker assays in support of drug development.
• Experience with multiplex tissue‑based spatial profiling assays (e.g., multiplex immunofluorescence, multiplex chromogenic immunohistochemistry, imaging mass cytometry, spatial transcriptomics).
• Familiarity with clinical grade whole slide imaging platforms (e.g., Leica Aperio, Hamamatsu, Roche DP 600).
• Proficiency in commercial or open‑source image analysis software packages (e.g., Visiopharm, HALO, QuPath).
• Knowledge of using statistical software packages (e.g., Prism, SPSS).
• Understanding of regulated clinical bioanalysis.

The salary range for this role is $ – $. Salary decisions within this range will be based on relevant education, qualifications, certifications, experience, skills, geographic location, government requirements, and business or organizational needs.

Eligible for annual bonus and long‑term incentive, if applicable.

Benefits include medical, dental, vision, healthcare and other insurance benefits for employee and family, retirement benefits (including 401(k)), paid holidays, vacation, and compassionate and sick days. More information about benefits is available at

We are an Equal Employment Opportunity Employer and provide equal opportunities to all employees and applicants for employment. We prohibit discrimination on the basis of race, color, age, religion, sex, sexual orientation, gender identity, national origin, protected veteran status, disability status, or any other legally protected characteristics. As a federal contractor, we comply with all affirmative action requirements for protected veterans and individuals with disabilities.

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