Associate Scientist - Downstream Process Development

Associate Scientist-Downstream Process Development

Join a dynamic and innovative team dedicated to advancing gene therapy processes. This role is perfect for individuals passionate about hands-on process development and eager to contribute to a growing team. You will have the opportunity to take ownership of experiments and directly influence the development of groundbreaking therapies.

Responsibilities

• Design, setup, and execute chromatography runs, including column packing, buffer preparation, method programming, and chromatography skid operation.
• Design, setup, and execute TFF/UFDF runs involving tubing and filter assembly, as well as TFF skid operation.
• Execute TECAN/robocolumn purification methods.
• Handle sample submission logistics for both internal and external testing.
• Perform general downstream tasks to ensure the smooth operation of the lab, such as buffer preparation, column packing, and tracking critical downstream-specific consumables.
• Prepare technical reports and presentations of experimental data, presenting findings, conclusions, and next steps to the larger Tech Ops team.

Essential Skills

• 1 – 3 years of experience in downstream process development.
• Proficiency in ÄKTA (UNICORN) method writing.
• Experience in column packing, buffer design & preparation, and filtration.

Additional Skills & Qualifications

• Experience with TFF skid operation.
• Experience with liquid handlers such as TECAN or similar.
• Experience with scale-up and scale-down models in various unit operations.
• Proficiency in sterile/aseptic techniques and low-endotoxin prep.
• Experience with tech transfer and batch record document writing and review.

Work Environment

This role follows a hybrid work schedule, requiring on-site presence 4 days a week with 1 day remote. Depending on lab workload, full 5-day onsite attendance may be required. The standard schedule is from 9am to 5pm. You will support a close-knit team currently consisting of 2 members, providing crucial assistance given their 5-project workload.

Job Type & Location

This is a Contract to Hire position based out of Boston, MA.

Pay and Benefits

The pay range for this position is $43.00 - $48.00/hr eligibility requirements apply to some benefits and may depend on your job classification and length of employment. Benefits are subject to change and may be subject to specific elections, plan, or program terms. If eligible, the benefits available for this temporary role may include the following:
• Medical, dental & vision
• Critical Illness, Accident, and Hospital
• 401(k) Retirement Plan – Pre-tax and Roth post-tax contributions available
• Life Insurance (Voluntary Life & AD&D for the employee and dependents)
• Short and long-term disability
• Health Spending Account (HSA)
• Transportation benefits
• Employee Assistance Program
• Time Off/Leave (PTO, Vacation or Sick Leave)

Workplace Type

This is a fully onsite position in Boston, MA.

Final date to receive applications

This position is anticipated to close on Jul 20, 2026.