Associate Scientist - Downstream Process Development

Job Title:

Associate Scientist-Downstream Process Development

Join a dynamic and innovative team dedicated to advancing gene therapy processes. This role is perfect for individuals passionate about hands‑on process development and eager to contribute to a growing team. You will have the opportunity to take ownership of experiments and directly influence the development of groundbreaking therapies.

• Design, set up, and execute chromatography runs, including column packing, buffer preparation, method programming, and chromatography skid operation.
• Design, set up, and execute TFF/UFDF runs involving tubing and filter assembly, as well as TFF skid operation.
• Execute TECAN/robocolumn purification methods.
• Handle sample submission logistics for both internal and external testing.
• Perform general downstream tasks to ensure the smooth operation of the lab, such as buffer preparation, column packing, and tracking critical downstream‑specific consumables.
• Prepare technical reports and presentations of experimental data, presenting findings, conclusions, and next steps to the larger Tech Ops team.

• 1 – 3 years of experience in downstream process development.
• Proficiency in ÄKTA (UNICORN) method writing.
• Experience in column packing, buffer design & preparation, and filtration.

• Experience with TFF skid operation.
• Experience with liquid handlers such as TECAN or similar.
• Experience with scale‑up and scale‑down models in various unit operations.
• Proficiency in sterile/aseptic techniques and low‑endotoxin prep.
• Experience with tech transfer and batch record document writing and review.

This role follows a hybrid work schedule, requiring on‑site presence 4 days a week with 1 day remote. Depending on lab workload, full 5‑day onsite attendance may be required. The standard schedule is from 9am to 5pm. You will support a close‑knit team currently consisting of 2 members, providing crucial assistance given their 5‑project workload.

This is a Contract to Hire position based out of Boston, MA.

The pay range for this position is $43.00 - $48.00/hr.

Eligibility requirements apply to some benefits and may depend on your job classification and length of employment. Benefits are subject to change and may be subject to specific elections, plan, or program terms.

If eligible, the benefits available for this temporary role may include the following:

• Medical, dental & vision
• Critical Illness, Accident, and Hospital
• 401(k) Retirement Plan – Pre‑tax and Roth post‑tax contributions available
• Life Insurance (Voluntary Life & AD&D for the employee and dependents)
• Short and long‑term disability
• Health Spending Account (HSA)
• Transportation benefits
• Employee Assistance Program
• Time Off/Leave (PTO, Vacation or Sick Leave)

This is a fully onsite position in Boston, MA.

This position is anticipated to close on Jul 20, 2026.

The company is an equal opportunity employer and will consider all applications without regard to race, sex, age, color, religion, national origin, veteran status, disability, sexual orientation, gender identity, genetic information or any characteristic protected by law.

If you would like to request a reasonable accommodation, such as the modification or adjustment of the job application process or interviewing process due to a disability, please email actalentaccom for other accommodation options.

San Francisco Fair Chance Ordinance:
Pursuant to the San Francisco Fair Chance Ordinance, for all positions located in the city and county of San Francisco, we will consider for employment qualified applicants with arrest and conviction records.

Massachusetts Lie Detector:
It is unlawful in Massachusetts to require or administer a lie detector test as a condition of employment or continued employment. An employer who violates this law shall be subject to criminal penalties and civil liability.

Use of Artificial Intelligence (AI):
We may use Artificial Intelligence (AI) to support parts of our hiring process, including sourcing, screening, and evaluating candidates. AI helps assess applications and qualifications, but final decisions are made by our hiring team. By applying, you acknowledge and agree that your application may be reviewed using AI tools.