Chemist; R1-R5

At Lilly, we unite caring with discovery to make life better for people around the world. We are a global healthcare leader headquartered in Indianapolis, Indiana. Our employees work to discover and bring life‑changing medicines to those who need them, improve disease understanding and management, and give back through philanthropy and volunteerism.

• Perform quantitative analysis in support of RNA therapeutics development.
• Identify metabolites of oligonucleotides using high‑resolution mass spectrometry and liquid chromatography‑mass spectrometry.
• Design and conduct in vitro and in vivo studies to assess siRNA‑based modalities for efficacy, exposure, potency, and durability.
• Enable platform development through in vitro stability assays.
• Conduct analytical assay development for siRNA‑based modalities in connection with pre‑portfolio, portfolio, and candidate selection.
• Develop analytical methods to support antibody‑conjugated siRNA programs.
• Develop alternative methods for tissue homogenization to improve throughput and sensitivity.
• #LI‑DNI

• Bachelor’s degree in Chemistry, Biochemistry, Pharmaceutical Science, or a related field.
• Minimum of 3 years experience performing quantitative biochemical analyses in an industrial or research setting.
• 3 years experience leveraging high‑performance liquid chromatography‑mass spectrometry (HPLC‑MS) for bioanalysis.
• 3 years experience with high‑resolution mass spectrometry tools, including Orbitrap/TOF.
• 3 years experience handling biological tissues and fluids in a research laboratory setting.
• 3 years experience conducting oligonucleotide bioanalysis.
• Up to 5% domestic and international travel required.

Job location:

Boston, MA.

To apply, please visit  and enter job requisition number R‑103511 when prompted. Alternatively, send your resume, cover letter, and a copy of the ad to Matthew Tenaglio, Lilly Corporate Center, Indianapolis, IN 46285.

Lilly is dedicated to helping individuals with disabilities to actively engage in the workforce, ensuring equal opportunities when vying for positions. If you require accommodation to submit a resume for a position at Lilly, please complete the accommodation request form  for further assistance. Please note this is for individuals to request an accommodation as part of the application process and any other correspondence will not receive a response.

Lilly is proud to be an EEO Employer and does not discriminate on the basis of age, race, color, religion, gender identity, sex, gender expression, sexual orientation, genetic information, ancestry, national origin, protected veteran status, disability, or any other legally protected status.

Actual compensation will depend on a candidate’s education, experience, skills, and geographic location. The anticipated wage for this position is $ – $ per year.

Full‑time equivalent employees are also eligible for a company bonus (depending, in part, on company and individual performance). In addition, Lilly offers a comprehensive benefit program to eligible employees, including eligibility to participate in a company‑sponsored 401(k), pension, vacation benefits, medical, dental, vision, and prescription drug benefits, flexible benefits (e.g., healthcare and/or dependent day care flexible spending accounts), life insurance and death benefits, certain time off and leave of absence benefits, and well‑being benefits (e.g., employee assistance program, fitness benefits, and employee clubs and activities).

Lilly reserves the right to amend, modify, or terminate its compensation and benefit programs in its sole discretion and Lilly’s compensation practices and guidelines will apply regarding the details of any promotion or transfer of Lilly employees.