Scientist (all levels) – Radiopharmaceutical Development

Aktis Oncology, Inc. is a clinical-stage oncology company focused on expanding the breakthrough potential of targeted radiopharmaceuticals to large patient populations, including those not addressed by existing platform technologies. Aktis’ most-advanced program, AKY-1189, is a mini protein radio conjugate targeting Nectin-4, with multi-indication potential across multiple tumor types, including locally advanced or metastatic urothelial cancer, breast cancer, non-small cell lung cancer, colorectal cancer, cervical cancer, and head and neck cancer.

Aktis’ second pipeline program, AKY-2519, is a mini protein radio conjugate targeting B7-H3 expressing tumors, including prostate, lung and other solid tumors. Aktis has a strategic collaboration with Eli Lilly and Company to leverage its mini protein platform to develop novel radio conjugates outside of Aktis’ proprietary pipeline.

Description

Aktis Oncology is seeking highly motivated scientists to support manufacturing and QC development of AKTIS Oncology’s proprietary radiopharmaceutical drug products. The candidate will be part of radiolabeling development, formulation optimization, and establishment of initial analytical methods within the RPD group. These roles are critical in ensuring product quality, regulatory compliance, and successful advancement of radiopharmaceutical programs from early development through clinical manufacturing.

The position(s) will collaborate closely with cross-functional team members to ensure timely delivery of robust manufacturing protocols in support of technology transfer activities. The ideal candidate has hands‑on experience in radiolabeling and handling radioactive materials and radiopharmaceutical analytical techniques. This role requires full‑time on‑site presence at the Aktis Boston office.

Responsibilities

This role will drive several areas of strategic importance to Aktis:

• Radiolabeling and analytical method development of Aktis’ radioactive drug products for pre‑clinical and early phase clinical use.
• Participate in day‑to‑day laboratory operations, including radiation safety.
• Write development reports that can be used for transfer of technology and regulatory filing.
• Take on new challenges willingly and build a culture of rigor and data‑driven decision making to bring novel therapies to the clinic
• Demonstrate high standards for scientific rigor, team behaviors, excellence and a culture of innovation that is fully aligned with company objectives
• Operate and maintain radio‑HPLC systems, detectors, and analytical instruments

Qualifications

• Minimum BS in chemistry, engineering or related field, with relevant industry experience
• Hands‑on experience with metal chelation chemistry, radiolabeling methods and handling radioactive materials.
• Experience analyzing radio labeled compounds, experience with gamma detectors, UV‑and radio‑HPLC
• Experience with protein solubility, binding assays, and drug product formulation
• Experience with HPLC troubleshooting and maintenance
• Project management and organizational skills, proven track record of setting priorities, and ability to work independently and as a team member.
• Strong desire to be part of a mission‑oriented company leading transformative change for patients.
• Proven demonstration of transparent communication and fostering open and diverse debate.
• Ability to work with agility and manage ambiguity.
• Personifies positive energy and exemplifies respect.

Aktis Oncology is an Equal Opportunity Employer and does not discriminate on the basis of race, religion, color, sex, gender identity or expression, sexual orientation, age, disability, national origin, veteran status, or any other basis covered by appropriate law. Aktis Oncology is committed to promoting and maintaining a work environment in which all applicants, employees, and other individuals are treated with dignity and respect free from unlawful harassment, discrimination, or retaliation.