Biorepository Core Manager - Breast Oncology

Breast Oncology Translational Research Biorepository Manager will oversee the management of the DF/HCC Breast Program’s translational research biorepository in its support of collecting, processing, storing, cataloging, and providing biospecimens for clinical trials, cohort studies, and translational research. Leads the development and maintenance of the wet lab infrastructure, supervises research technicians and clinical research coordinators in accordance with the research experimental policies and procedures for the clinical trials, cohort studies and specific translational research studies.

Ultimately responsible for the day-to-day lab operations of the biorepository in that they adhere to safety guidelines and meet the objectives and standard operating procedures of all of the research studies and clinical trials. Act as the main point of contact for Principal Investigators and their study teams in the planning and execution of biospecimen collection for new study startups and design of transitional studies.

Oversees specimen entry into the biorepository, collating and sharing specimens under appropriate IRB approvals, and working directly with the Co-Chairs of the DF/HCC Breast Clinical Data and Biospecimens Users Committee to oversee and manage, review, and execute biospecimen requests.

Located in Boston and the surrounding communities, Dana-Farber Cancer Institute is a leader in life changing breakthroughs in cancer research and patient care. We are united in our mission of conquering cancer, HIV/AIDS, and related diseases. We strive to create an inclusive, diverse, and equitable environment where we provide compassionate and comprehensive care to patients of all backgrounds, and design programs to promote public health particularly among high-risk and underserved populations.

We conduct groundbreaking research that advances treatment, we educate tomorrow's physicians/researchers, and we work with amazing partners, including other Harvard Medical School-affiliated hospitals.

Primary Duties and Responsibilities:

• Lead biorepository operations and chain-of-custody:
  Direct end-to-end specimen operations including receipt, accessioning, storage, retrieval, and secure transport between locations; ensure accurate labeling, documentation, and chain-of-custody practices aligned to protocol requirements, institutional standards, and applicable regulatory expectations.
• Own inventory integrity and system-of-record performance:
  Manage specimen inventory control and reconciliation processes; ensure physical inventory aligns with electronic records; establish routine data-quality checks and corrective actions to maintain reliable, audit-ready documentation.
• Administer biorepository informatics (Open Specimen) and access workflows:
  Build and maintain study/protocol configuration (e.g., protocol setup, label design/testing, user access), partner with study teams on study start-up and amendments, and coordinate with internal technology resources to optimize functionality and reporting.
• Oversee billing, budgeting, and recharge operations:
  Manage iLabs account setup and service workflows, develop/track quotes and purchase orders as applicable, consolidate and reconcile monthly charges, and coordinate submission of billing charges/journal entries with Research Administration; monitor operational expenses and implement mitigation actions as needed.
• Manage freezer farm and critical equipment readiness:
  Oversee freezers and supporting laboratory equipment across sites, including maintenance/service coordination, calibration/maintenance documentation, relocations, sensor installation and monitoring coordination (e.g., with CAMS), review of temperature trends, and defined escalation/response processes for critical alarms, including after-hours coverage as needed.
• Drive SOPs, quality systems, and audit readiness:
  Develop, maintain, and implement SOPs and work practices; ensure staff training and adherence; maintain required records (e.g., temperature charts, calibration logs, inventory reports) and coordinate sponsor/customer audits and follow-up actions.
• Provide people leadership and workforce planning:
  Assess staffing needs and recommend resourcing; recruit, schedule, train, and develop staff across locations; set clear expectations, provide feedback, ensure cross-training/coverage, and foster a culture of safety, service, inclusion, and continuous improvement.

Knowledge, Skills and Abilities:

• Working knowledge of biorepository or clinical…