Director, HEOR – Orexin Franchise

Centessa Pharmaceuticals, a wholly owned subsidiary of Eli Lilly and Company, is a clinical-stage company developing orexin receptor 2 (OX2R) agonists as a new class of medicines for the treatment of narcolepsy and potentially other sleep-wake disorders. Centessa’s lead investigational candidate – cleminorexton (formerly ORX
750) – is being developed for narcolepsy type 1, narcolepsy type 2, and idiopathic hypersomnia. Centessa's OX2R agonist portfolio includes additional clinical and preclinical-stage assets with potential utility across a broader range of neurological, neurodegenerative, and neuropsychiatric conditions.

Headquartered in Boston, Massachusetts, Centessa was recognized as a Great Place to Work
® in 2026.

Centessa is seeking a Director, Health Economics and Outcomes Research (HEOR) to lead the development and execution of HEOR strategies across the central disorders of hypersomnia portfolio. In this role you will lead robust evidence generation strategies that to deliver global and regional evidence to support regulatory requirements, HTA dossiers, and payer negotiations, for Centessa’s Orexin Franchise. Reporting to the Executive Director, HEOR, the, you will partner extensively with Medical Affairs, Clinical Development, Market Access, Commercial, Legal, Regulatory, and external research partners to translate strategic objectives into actionable, well-governed research plans throughout the product lifecycle — from early pipeline evidence generation and launch readiness through post-launch value demonstration.

• Lead the development of comprehensive HEOR strategies and operational plans for the assigned asset, establishing an early value proposition and sustaining value demonstration.
• Identify and address unmet medical needs, access barriers, and value gaps in collaboration with cross-functional teams to inform evidence and value narratives.
• Collaborate with cross-functional stakeholders to identify evidence needs and translate strategic objectives into actionable, accountable research plans.
• Design and incorporate PRO strategies into clinical development plans and support early market access planning.
• Maintain current knowledge of the regulatory, payer, and policy landscape relevant to PRO use, and assess implications for evidence generation.

• Lead and manage HEOR studies, including retrospective and prospective observational studies, database analyses (claims, EHR, registries), and innovative designs such as external control arms to contextualize single-arm trial data.
• Support the development of health economic models, AMCP dossiers, value communication materials and literature reviews to support launch readiness and ongoing value demonstration.
• Ensure all research initiatives adhere to internal study governance and scientific/ethical standards, including securing necessary approvals and cross-functional alignment.
• Manage external vendors, consultants, CROs, and research partners to ensure high-quality, on-time study execution and appropriate budget management.
• Measure and track the impact of generated evidence, translating research outputs into practical tools (e.g., value decks, field materials) in partnership with scientific communications and patient advocacy team members.

• Communicate study findings, evidence strategy, and strategic impact to internal stakeholders, including Medical Affairs and functional leadership, and contribute to training and education efforts.
• Support the development of scientific publications, congress presentations and other scientific communications for technical and non-technical audiences.
• Represent Centessa at…