Scientist , Biology

Code breaker is building a modern functional genomics research engine to connect human genetic variation to cellular function at scale.

This is a hands-on laboratory scientist role. You will execute genetic screening, cell engineering and phenotyping workflows across challenging human cell models, including primary T cells, other primary cells, fibroblasts and iPSC/iPSC-derived systems. Working closely with Senior Scientists and the Director of Biology, you will contribute to experimental planning, execution, troubleshooting and data analysis while developing increasing independence in experimental design and interpretation.

You will partner closely with computational biology and machine learning colleagues and use modern AI tools as part of your daily scientific workflow to improve the quality, speed and scope of what the team can accomplish. You should genuinely enjoy experimental work, take ownership of problems, prioritize what matters most, move quickly, and put in the extra effort when an experiment or troubleshooting requires it.

• Execute high-throughput functional genomics programs using CRISPR and related perturbation technologies in human cells.
• Culture and execute workflows for technically demanding human cell systems — including primary T cells, other primary cells, fibroblasts and iPSC/iPSC-derived models — according to established experimental plans.
• Apply phenotyping approaches, ideally including single-cell RNA-seq and other single-cell or multi-omic readouts, flow cytometry, and functional cellular assays.
• Identify opportunities to improve established assays and workflows, and contribute to their implementation.
• Contribute to experimental planning and data analysis, and work with computational colleagues to ensure data are accurately structured and annotated.
• Perform careful experimental execution, troubleshooting, quality control and documentation, escalating complex issues appropriately.
• Maintain detailed and reproducible documentation of experiments, protocols and results using ELN/LIMS and other appropriate systems.
• Use AI-enabled tools where appropriate to support experimental planning, execution, documentation and data analysis.
• Present experimental results and progress updates to the research team, and contribute to internal documentation and, where appropriate, publications and external presentations.
• Collaborate closely with Senior Scientists, research associates and computational colleagues to support research program objectives.

• MS or PhD in immunology, molecular biology, genomics, cell biology or a related field, with relevant hands-on laboratory research experience.
• Hands-on experience in mammalian cell culture, ideally with challenging cell models (e.g. primary cells and/or iPSCs), and with CRISPR-based gene editing or related screening technologies — or strong readiness to develop this expertise quickly.
• Familiarity with phenotypic characterization techniques such as flow cytometry, sequencing-based assays or functional immune assays.
• Solid quantitative and analytical skills; comfortable working with structured datasets, standard data analysis tools (e.g. R, Python) and AI-assisted analysis tools — or motivated to build these skills.
• Strong attention to detail, record-keeping and communication skills.
• Ability to work both independently on well-defined tasks and collaboratively within a team-based research environment.
• Strong work ethic and eagerness to get things done. You show up ready to prioritize the most important task in front of you, move quickly, and are willing to put in extra time when an experiment or deadline calls for it.

• Prior experience with human cell culture (e.g. primary cells or…