Protein Crystallographer

PE Global is currently recruiting for a Protein Crystallographer on behalf of a leading global biopharmaceutical organisation on a 12-month contract basis.

Based at a state-of-the-art research facility in Bracknell
, this hybrid contract role will suit an experienced structural biologist with a strong background in protein crystallography and fragment-based ligand discovery (FBLD).

• Location: Bracknell, Berkshire
• Working Pattern: Hybrid (2 days per week on site)
• Rate: £28.54 – £38.01 per hour depending on experience.

*** Please note our client cannot assist with any visa sponsorship, and candidates must have the correct visa to live and work in UK for at least 12 months***

• Utilise low‑occupancy crystallography software and standard refinement packages to efficiently model and refine outputs from crystallographic fragment screening campaigns.
• Coordinate X‑ray data collection activities using internal synchrotron resources, external synchrotron facilities, and contract research organisations (CROs).
• Design, execute, and analyse fragment screening experiments using X‑ray crystallography.
• Collaborate with internal and external scientific partners to develop cutting‑edge crystallography methods, including approaches for identifying and characterising cryptic binding pockets.
• Support fragment progression through iterative design cycles, including fragment growth, linking, and merging strategies.
• Process and interpret large volumes of crystallographic datasets in parallel.
• Contribute to the continuous improvement of structural biology workflows, automation, and data quality standards.

• PhD in Structural Biology, Biochemistry, Chemical Biology, Chemistry, or a related scientific discipline.
• Significant hands‑on experience in protein crystallography, including solving large numbers of protein‑fragment crystal structures and processing extensive datasets in parallel.
• Demonstrable experience delivering fragment screening campaigns using X‑ray crystallography.
• Strong expertise with crystallography software including PHENIX and BUSTER
  .
• Experience using FBLD‑related software (Maestro/Schrödinger, ICM‑Pro, GINGER, FrankenROCS, Fragment stein, cluster4x, PanDDA)
• Experience scripting and automating crystallography workflows, ideally within a High‑Performance Computing (HPC) environment.

Interested candidates should submit an updated CV. Please click the link below to apply.

*** Please note our client cannot assist with any visa sponsorship, and candidates must have the correct visa to live and work in UK***