ViiV Healthcare Scientific Leader, Nonclinical Drug Discovery Modeling

ViiV Healthcare is a global specialty HIV company focused on research and delivering new medicines for people living with or at risk of HIV.

We seek a Scientific Leader, Nonclinical Drug Discovery Modeling to develop and apply fit‑for‑purpose modeling and simulation approaches within ViiV Discovery.

Location:

Branford, CT – eligible for a domestic relocation package.

• Apply fit‑for‑purpose modeling and simulation approaches to support decision‑making across HIV discovery programs.
• Develop and execute mechanistic and translational models (e.g., PBPK, IVIVE, PK/PD) to support dose prediction, compound optimization, and candidate selection.
• Integrate experimental data into predictive workflows and translate ADME, PK, PD, and translational data into actionable project insights.
• Apply modeling expertise across diverse modalities, formulations, and routes of administration, including long‑acting therapies.
• Guide program teams toward the identification and advancement of high‑quality clinical candidates.
• Contribute to modeling workflows, computational tools, and reproducible coding practices.
• Collaborate with Chemistry, Biology, DMPK, and Clinical Pharmacology teams to support program objectives and dose prediction strategies.
• Communicate modeling results and recommendations to multidisciplinary project teams.
• Support modeling best practices and contribute to innovation through new methodologies and technologies.
• Contribute to scientific publications, regulatory documentation, and knowledge sharing within the modeling community.

• MS Degree with 7+ years of experience or PhD with 4+ years of post‑graduation experience supporting drug discovery programs.
• Experience with modeling platforms (e.g., SimCYP, Gastro Plus, Win Non Lin ) and basic scripting experience (e.g., R, MATLAB, Python).
• Ability to apply mechanistic modeling approaches to support discovery programs and to progress rapid decisions.
• Experience with integrating experimental datasets into modeling workflows.
• Familiarity with reproducible coding practices and version control.
• Experience in PK/PD, PBPK, or IVIVE modeling approaches.
• Ability to interpret results and communicate to cross‑functional teams.

• PhD with 6+ years of drug discovery experience.
• Experience working across teams, including partnering with internal and external experts.
• Excellent written, verbal, and presentation skills, including experience communicating scientific concepts to cross‑functional teams and stakeholders.
• Strong data visualization and numerical analysis capabilities.

All ViiV employees receive the same benefit options and plans as GSK employees. For more information, visit GSK US Benefits Summary.

ViiV is an Equal Opportunity Employer. This ensures that all qualified applicants will receive equal consideration for employment without regard to race, color, religion, sex (including pregnancy, gender identity, and sexual orientation), parental status, national origin, age, disability, genetic information (including family medical history), military service or any basis prohibited under federal, state or local law.