Principal Scientist, DMPK

Job Summary

The Principal Scientist, DMPK is responsible for planning and performing in vitro and in vivo ADME studies that contribute to PTC's research and development activities. The incumbent communicates experimental results to supervisors and project teams, works cross‑functionally with internal departments and external resources, and supports regulatory compliance and SOP adherence.

• Plan, initiate, and execute DMPK studies under limited direction and interpret results as part of a multidisciplinary team.
• Collaborate with R&D teams to schedule and conduct DMPK studies aligned with development candidate nominations and IND/NDA timelines.
• Serve as the DMPK representative on project teams, interpreting and presenting data to cross‑functional members, both internal and external.
• Perform hands‑on in vitro and in vivo DMPK studies, including metabolic stability, metabolite profiling, CYP inhibition and induction, pharmacokinetics, and radio labeled studies in lab animals and humans.
• Document experiments in a laboratory notebook, write reports, and prepare DMPK documents for nomination and IND/NDA purposes.
• Ensure scientific quality of experimental data.
• Oversee and/or lead interactions with external Contract Research Organizations (CROs).
• Abide by all safety and regulatory guidelines.
• Contribute to general lab needs such as:
  • Equipment maintenance
  • Troubleshooting
• Perform other tasks and assignments as needed and specified by management.

• PhD in Chemistry, Biology, Pharmaceutical Science, Pharmacology, or related discipline with a minimum of 5 years of drug‑metabolism experience, OR a Master’s degree with a minimum of 6+ years in the same field.

• Hands‑on experience in conducting in vitro and in vivo DMPK studies.
• Demonstrated expertise in drug metabolism, biotransformation, pharmacokinetics, pharmacodynamics, and bioanalytical principles.
• Hands‑on experience using contemporary LC‑MS/MS instruments.
• Experience developing protocols and writing study reports, and other relevant documentation for IND/NDA purposes.
• Ability to work on complex problems producing experimental data across multiple projects.
• Effective teamwork in a multidisciplinary environment.
• Proficiency with Microsoft Office.
• Excellent verbal and written communication skills.
• Ability to work independently and collaboratively in a fast‑paced, matrixed, team environment.
• Analytical thinker with strong problem‑solving skills and adaptability to changing priorities.
• Excellent planning, organization, and time‑management skills to support and prioritize multiple projects.

• PhD (additional advantage).
• Knowledge of and experience in conducting radio labeled studies.
• Hands‑on experience operating and troubleshooting contemporary LC‑MS instruments and automated liquid handlers.
• Prior experience with INDs and/or NDAs.
• Hands‑on experience with cell‑based (hepatocytes, transporters, etc.) assays.
• Proficiency in using Win Nonlin or other pharmacokinetic software.

• 0‑10% travel.
• Laboratory‑based position.

Expected base salary range: $153,500 – $185,000, contingent upon assessment of education, background, and experience. In addition to base salary, eligible employees may receive short‑ and long‑term incentives and enroll in medical, dental, vision, and retirement savings plans.

PTC Therapeutics is an equal opportunity employer. We welcome applications from all individuals, regardless of race, color, national origin, gender, age, physical characteristics, social origin, disability, religion, family status, pregnancy, sexual orientation, gender identity, gender expression, veteran status or any unlawful criterion under applicable law. We are committed to treating all applicants fairly and avoiding discrimination.