Senior Scientist

Company Description

Abb Vie's mission is to discover and deliver innovative medicines and solutions that solve serious health issues today and address the medical challenges of tomorrow. We strive to have a remarkable impact on people's lives across several key therapeutic areas including immunology, oncology and neuroscience - and products and services in our Allergan Aesthetics portfolio. For more information about Abb Vie, please visit us at  Follow @abbvie on Linked In, Facebook, Instagram, X and You Tube.

We are looking for a motivated candidate to support late-stage process development of Antibody-Drug-Conjugates (ADCs) and other emerging conjugation modalities. Primarily, the candidate will independently design and perform conjugation experiments, perform downstream operations such as Tangential Flow Filtration (TFF) purifications, and analyze experimental and analytical results – either running analyses independently or via sample submission to Analytical Development colleagues. This late-stage development work will ultimately support process characterization, commercialization, and regulatory submissions for ADC therapies in Abb Vie’s development pipeline.

The candidate is expected to work with managers and key stakeholders or collaborators to effectively plan and communicate experimental timelines and results. ADC development work is inherently interdisciplinary and cross-functional, so a strong candidate will be able to quickly learn and develop functional knowledge of adjacent development areas to understand how those interface with conjugation process development.

• Maintain a high degree of productivity in lab to support conjugation process development: independently design, execute, and interpret key experiments to answer scientific questions.
• Perform conjugation and purification operations at reaction scales ranging from ~mL scale reactions up to a 10L reactor.
• Perform routine sample preparation and operation of HPLC-based analytical assays.
• Understand scale dependence of chemical reactions or purifications, or engineering scale factors.
• Document and share results via electronic laboratory notebooks, internal technical presentations, and technical reports.
• Learn, understand, and master relevant laboratory techniques, and serve as a subject matter expert and mentor for junior scientists in lab.
• The candidate will understand and adhere to corporate standards regarding code of conduct, safety and GXP compliance.
• Work collaboratively within a multi-disciplinary team, including analytical chemists, process chemists, and manufacturing personnel.

• BS with 10+ years', MS with 8+ years', and PhD with 0+ years' industry experience.
• Degreein chemistryor chemical engineering.
• Strong scientific communication and interpersonal skills to drive collaboration within the conjugation process development team and with cross-functional partners.
• Thorough understanding of organic chemistry, theoretical conceptualization of reaction mechanisms, and practical ‘fluency’ with wet-lab operations and running chemical reactions.
• Extremely knowledgeable in HPLC/UPLC instruments: familiar with equipment care and maintenance best practices for shared lab equipment, ability to perform basic troubleshooting of HPLC systems.
• Ability to multitask and meet timelines.

• Prior experience with drug-conjugate chemistry or conjugation process development is not necessary but strongly preferred.
• Advanced degree (MS or PhD) inorganic chemistry, or experience in small molecule chemistry.
• Experience in design-of-experiments (DoE), quality-by-design (QbD), and development of statistical and mathematical models.

Applicable only to applicants applying to a position in any location with pay disclosure requirements under state or local law:

• The compensation range described below is the range of possible base pay compensation that the Company believes in good faith it will pay for this role at the time of this posting based on the job grade for this position. Individual compensation paid within this range will depend on many factors including geographic…