Postdoctoral Scientist – Ocaas Lab

Position Overview and Responsibilities

The Ocaas Lab at the Oklahoma Medical Research Foundation is seeking a motivated postdoctoral researcher interested in women’s health, ovarian biology, brain aging, neurodegeneration, inflammation, and/or single‑cell and multi‑omic approaches to aging biology. Our lab studies how aging and sex‑specific biology shape inflammatory and degenerative processes across tissues with a particular focus on the ovary and brain. Current projects investigate mechanisms of ovarian aging, immune cell remodeling, neuroinflammation, microglial biology, Alzheimer’s disease, and the molecular links between reproductive aging and brain health.

We use mouse models, single‑cell transcriptomics, epigenomics, spatial and molecular biology approaches, and computational analyses to understand how aging‑associated inflammatory pathways contribute to tissue dysfunction and disease. The postdoctoral scientist will lead independent and collaborative projects focused on mechanisms of ovarian aging, women’s health, brain aging, and/or neurodegeneration. The position offers opportunities to develop expertise in animal models, molecular biology, tissue imaging, flow cytometry, single‑cell genomics, bioinformatics, and translational aging research.

• Developing and leading research projects related to ovarian aging, inflammation, brain aging, or neurodegenerative disease
• Designing and performing experiments using mouse models, tissue collection, histology, immunofluorescence, flow cytometry, molecular assays, and/or sequencing approaches
• Analyzing and interpreting experimental data, including single‑cell transcriptomic, epigenomic, or other multi‑omic datasets, depending on candidate interests and expertise
• Preparing manuscripts, abstracts, figures, presentations, and fellowship or grant applications
• Presenting research findings at lab meetings, institutional seminars, and national or international conferences
• Contributing to a collaborative and inclusive lab environment, including mentoring junior trainees and working closely with other lab members and collaborators

• PhD in a biological science such as neuroscience, physiology, reproductive biology, genomics, bioinformatics, chemistry, physics, or other relevant area;
  MD or equivalent degree accepted
• Strong interest in women’s health, ovarian biology, aging, neurodegeneration, inflammation, or related areas
• Experience with experimental design, data analysis, and scientific writing
• Ability to work independently while contributing to a collaborative team environment
• Strong communication, organizational, and problem‑solving skills

• Experience with reproductive biology, ovarian biology, neuroscience, aging biology, immunology, neuroinflammation, Alzheimer’s disease, or sex‑difference research
• Experience with mouse models, tissue dissection, histology, immunostaining, microscopy, flow cytometry, molecular biology, or sequencing library preparation
• Experience analyzing RNA‑seq, single‑cell RNA‑seq, ATAC‑seq, DNA methylation, spatial transcriptomics, or other high‑dimensional datasets
• Programming or data‑analysis experience in R, Python, or similar platforms
• Evidence of productivity including first‑author publications, conference presentations, or successful fellowship/grant applications
• Interest in developing an independent research program related to aging, women’s health, neurodegeneration, or reproductive biology

Founded in 1946, the Oklahoma Medical Research Foundation (OMRF) is among the nation's oldest and most respected independent nonprofit biomedical research institutes. OMRF is dedicated to understanding and developing more effective treatments for human diseases, focusing on critical research areas such as Alzheimer’s disease, cancer, lupus, multiple sclerosis, and cardiovascular disease. OMRF follows an innovative cross‑disciplinary approach to medical research and ranks among the nation's leaders in patents per scientist.

Located in Oklahoma City, OMRF offers a dynamic downtown area with low cost of living, short commute times, and a diversified economy. OMRF has been voted one of the Top Workplaces since the inception of the award.

Successful candidates will demonstrate commitment to this mission so that more may live longer, healthier lives.

We offer competitive salaries and comprehensive benefits to full‑time employees, including medical, dental, and vision insurance, a minimum of 8% company retirement contribution, vacation and sick leave, and paid holidays. All employees have access to an on‑site café, fitness center with personal trainer, free parking, and more. Relocation assistance is available for those located 50 miles outside of the Oklahoma City metro.

OMRF is an Equal Opportunity Employer.