Senior Principal Software Engineer

Description & Requirements

The Broad Institute, Genomics Platform is seeking a Senior Principal Software Engineer to help lead our Data Analysis & Operations team. This position will be instrumental in the development of our high‑scale cloud‑based orchestration platform for running genomics pipelines and performing data delivery. An ideal candidate will design, build, and maintain the necessary infrastructure while coordinating and leading the technical activities needed to support exciting new projects on the platform for both internal and external stakeholders.

This is a fast‑paced role that sits at the intersection of engineering, science, and business. A successful candidate will work effectively across multiple departments, partners, and with a wide community of computational biologists and medical/cancer geneticists. We are looking for a team player who thrives on opportunity, adapts well to change, and has a passion for making themselves, their teammates, and our partners better.

Here at Broad, our collaborators are large‑scale institutions—government, industry, academic, and philanthropic—that partner with us to generate clinical and genomic data, build new algorithms, and make all of this available to researchers through our open‑source analysis platform. We routinely partner with organizations across the biomedical ecosystem and with scientists in our local MIT, Harvard, and affiliated hospital neighborhood. Everything that goes on at the Broad, almost without exception, involves the use of specialized software.

Software engineers create our advanced algorithms, deliver solid infrastructure, and high quality portals.

• Bachelor's or advanced degree in Computer Science or related field with 15+ years of software development experience.
• Proven ability to deliver reliable, scalable, and maintainable systems.
• Ability to design, write, and read technical documents.
• Track record of delivering (or over delivering) on time.
• Comfortable presenting and communicating technical solutions to non-technical client stakeholders.
• Capable of understanding and translating technical requirements.
• Ability to perform effectively in a fast‑paced environment.
• Ability to learn new technologies and domains.
• A focus on outcomes and customer success.

• Experience with cloud environments (e.g., AWS, GCP).
• Familiarity with Apache Airflow is a plus.
• Experience integrating complex systems together.
• Experience with multiple programming languages, especially Python and Java.
• Experience working with relational databases and writing SQL queries.
• Experience troubleshooting and debugging complex systems.
• Experience with security practices within regulatory environments.
• Excellent communication skills and the ability to perform effectively in a fast‑paced environment.
• Must handle a variety of tasks, solve problems with numerous complex variables, and shift priorities rapidly.

The expected base salary range for this position is based on a 40‑hour per week schedule. Broad provides pay ranges representing its reasonable and good‑faith estimate of what the organization reasonably expects to pay for a role at the time of posting. Actual compensation will vary based on factors including but not limited to relevant skills, experience, education, qualifications, and other factors permissible by law.

At Broad, your base pay is just one part of a comprehensive total rewards package. From day one, this role offers a competitive benefits package including medical, dental, vision, life, and disability insurance; a 401(k) retirement plan; flexible spending and health savings accounts; at least 13 paid holidays; winter closure; paid time off; parental and family care leave; and an employee assistance program, among other Broad benefits.

The Broad Institute is an equal opportunity employer. All qualified applicants will receive consideration for employment without regard to race, national origin, religion, age, color, sex, disability, protected veteran status, or any other characteristic protected by local, state, or federal laws, rules, or regulations.

Should you need a reasonable accommodation to complete the application or interview process, please contact recruiting for assistance.