Senior Project Manager​/Associate Director, Discovery Project Management

Who We Are:

Xenon Pharmaceuticals (NASDAQ:XENE) is a neuroscience-focused biopharmaceutical company dedicated to drug discovery, clinical development, and commercialization of life-changing therapeutics for patients in need. We are looking for great people who thrive in a respectful, collaborative, inclusive, and productive culture to join the Xenon team.

We are advancing an exciting product pipeline to address indications with high unmet medical need, including epilepsy, depression and pain. Our Phase 3 azetukalner program represents the most advanced, clinically validated potassium channel modulator in late-stage clinical development for multiple indications. In March 2026, we announced positive topline data from our Phase 3 X-TOLE2 study of azetukalner in focal onset seizures (FOS), and we anticipate submitting a New Drug Application to the Food and Drug Administration in the third quarter of 2026.

Our Phase 3 epilepsy program also includes a second FOS study, X-TOLE3, which would support regulatory submissions outside the U.S., and the X-ACKT study in primary generalized tonic-clonic seizures, which would support regulatory submissions for an additional epilepsy indication. We also have multiple Phase 3 azetukalner clinical trials underway in major depressive disorder (MDD) and bipolar depression (BPD), based on topline data from our Phase 2 X-NOVA clinical trial.

In addition, we are proud of our strong heritage in human genetics, deep understanding of ion channel biology, and expertise in novel chemistries to enable potent, selective ion channel targeting. We continue to advance an early-stage pipeline of novel therapeutic candidates, including Phase 1 studies for XEN
1701 and XEN
1720 (targeting Nav
1.7) and XEN
1120 (targeting Kv7), which are being developed for pain. Backed by a strong balance sheet to support our growth plans, we continue to build a fully integrated, premier neuroscience company with strong discovery, clinical development, corporate, and commercial operations.

We are seeking a Senior Project Manager/Associate Director, Discovery Project Management to join our team. This individual will work flexibly across a number of Discovery-stage small molecule programs. This role involves close coordination with stakeholders within Discovery (e.g., Chemistry, Biology, Compound Properties, Toxicology and CMC) and outside of Discovery (e.g., Finance, Legal, QA, Development).

The position reports to the Director, Discovery Project Management and will be based out of Vancouver, BC, Canada. The level of the position will be commensurate with the candidate’s education and industry experience. Hybrid positions require a minimum of two onsite days per week.

• Develop and maintain comprehensive project/program/portfolio management and tracking tools addressing program scope, components, schedule and budget.
• Manage the Company’s Discovery-stage Contract Research Organizations (CROs) under both full-time equivalent and fee-for-service arrangements.
• Perform contract-related activities (drafting, contract change control, monitoring for performance, accepting deliverables, managing invoices and tracking accruals) relating to same within the scope of the Company’s contact management systems and policies.
• Coordinate Discovery-stage external studies including compound logistics, protocol drafting and review and communication with study directors.
• Coordinate project team, project sub-team, and functional group meetings for the Company’s Discovery stage programs. Track action items and timelines. Understand and communicate critical path towards key objectives. Schedule internal and external studies, as required.
• Facilitate cross-functional alignment with key Discovery stakeholders, identify potential cross-functional issues and bottlenecks across a multi-year horizon.
• Develop, optimize and manage data workflows and progression of compounds through program flowcharts. Ensure the timely distribution of externally-generated data and reports to appropriate stakeholders.
• Support activities that raise the scientific profile of the Company internally and externally, including…