Senior Automation Engineer II

Ready to redefine what’s possible in molecular diagnostics?

Join a team of brilliant, passionate innovators who wake up every day determined to transform healthcare. At Billion To One , we’ve built something extraordinary—a culture where transparency fuels trust, collaboration drives breakthroughs, and every voice matters in our mission to make life-changing diagnostics accessible to all. We don’t just aim for incremental improvements; we strive to build products that are 10x better than anything that exists today.

Our people are our greatest asset: talented scientists, engineers, sales professionals, and visionaries united by an unwavering commitment to changing the standard of care in prenatal and cancer diagnostics. This is where cutting-edge science meets human compassion—every innovation you contribute helps remove fear of unknown from some of life’s most critical medical moments. If you’re driven by purpose, energized by innovation, and ready to help build the future of precision medicine, this is where you belong.

We are looking for a Senior Automation Engineer II to join our growing Process Engineering team responsible for innovative solutions to support the high-complexity and high-growth clinical laboratory.
This is a high-growth role & will lead and manage projects to design and implement automation systems, as we continue to scale our laboratory by 10x over the next 12 months. This is a dynamic, start-up environment that requires adaptability and the ability to quickly learn and apply new concepts. The Senior Automation Engineer II role is a full-time onsite position and reports to the Associate Director, Service & Automation Engineering.

Responsibilities:

• Program Management & Strategy (50%)
• Lead Automation Programs:
  Drive the roadmap for laboratory automation projects from concept to deployment, managing timelines, scope, resource allocation, and risk assessments.
• Cross-Functional Collaboration:
  
  Act as the primary liaison between Clinical Ops, R&D, and Informatics/LIMS teams to translate biological requirements into technical specifications.
• Process Optimization:
  Analyze existing workflows to identify bottlenecks; design and implement robust process improvements to increase throughput and reduce error rates.
• Technical Execution & Systems Integration (50%)
• Platform Engineering:
  Design, script, and validate complex protocols on major liquid handling platforms (Hamilton STAR, Beckman Biomek i-Series, Agilent Bravo).
• LIMS & Data Integration:
  Lead integration efforts between liquid handlers and LIMS; utilize APIs/drivers to ensure seamless bi-directional data transfer and sample tracking.
• Validation & Compliance:
  Author and execute comprehensive validation packages (IQ/OQ/PQ), Standard Operating Procedures (SOPs), and user guides in compliance with CLIA/CAP/FDA regulations.
• Troubleshooting & Support:
  Serve as the final escalation point for complex hardware/software failures; provide advanced training and technical mentorship to junior engineers and lab operators.

Qualifications:

• BS or MS in Engineering (Biomedical, Mechanical, Systems), Biology, or a related field.
• 7+ years of hands-on experience in laboratory automation, with at least 2 years in a technical leadership or project management capacity.
• Deep expertise scripting on at least two major platforms (e.g., Hamilton Venus, Beckman Biomek, Agilent VWorks, or Tecan Evoware).
• Proven experience integrating third-party devices (readers, peelers, sealers) and interfacing with LIMS/LIS systems.
• Proficiency in at least one software language used for data parsing or system integration (Python, C#).
• Demonstrated ability to manage multiple concurrent projects using PM tools (e.g., Jira, Smartsheet) without direct supervision.
• Strong understanding of molecular biology workflows, specifically NGS library preparation (fragmentation, adapter ligation, enrichment).

Nice-to-Haves:

• Training certificates from major vendors (e.g., Hamilton Venus, Beckman Biomek).
• Experience with SQL database querying or cloud infrastructure (AWS/Azure) as it relates to lab data.
• Project Management Professional (PMP) or Agile/Scrum certification.
• Previous experience bringing automated…