Director, Medical Affairs - Immunology

Director, Medical Affairs – Immunology

Nurix Therapeutics is a clinical stage biopharmaceutical company focused on the discovery, development, and commercialization of targeted protein degradation medicines, the next frontier in innovative drug design aimed at improving treatment options for patients with cancer and inflammatory diseases. Powered by a fully AI-integrated discovery engine capable of tackling any protein class, and coupled with unparalleled ligase expertise, Nurix’s dedicated team has built a formidable advantage in translating the science of targeted protein degradation into clinical advancements.

Nurix aims to establish degrader-based treatments at the forefront of patient care, writing medicine’s next chapter with a new script to outmatch disease.

Nurix Therapeutics is seeking a Director, Medical Affairs – Immunology to lead medical strategy and execution for the company's Phase 2 immunology and inflammation (I&I) assets, with initial focus onbexobrutideg(NX-5948), an oral BTK degrader advancing into Phase 2 development in chronic spontaneous urticaria (CSU) and Multiple Sclerosis (MS) as part of Nurix'sglobal collaboration with Roche. This role owns the tactical medical affairs plan for the CSUand MSPhase 2programsend-to-end — from advisory input and KOL engagement through investigator relationships, field medical guidance, and evidence generation planning — and will expand scope as additional I&I assets advance through Phase 2.

Reporting to the Head of Medical Affairs, I&I, this leader will operate as the day-to-day scientific and strategic lead for the CSUand MS indications, translating emerging clinical and mechanism-of-action data into credible medical narratives for allergists, immunologists, dermatologists,neurologists and academic investigators. The role partners closely with Hematology,Clinical Development, Clinical Operations, HEOR, Regulatory, Legal, Compliance, and Nurix'sco-development partner Roche to ensure medical activities are aligned with the development plan and conducted compliantly.

• Own and execute the Medical Affairs tactical plan forbexobrutidegin CSUand MS, includingmedicalmessaging,advisory boards, congress strategy, publication planning, and scientific engagement priorities, in partnership with the Head of Medical Affairs, I&I.

• Translate Phase 1/2 clinical and translational data (e.g., BTK degradation,FcεRI-driven biology) into clear, credible medical narratives for external and internal audiences.

• Provide Medical guidance to the Field Medical team supporting the Immunology Pipelineincludingeducationpriorities, scientific training, and KOL engagement objectives.

• Build relationships withselectkey opinion leaders, allergists, immunologists, dermatologists,neurologists and academic investigators relevant to CSU,MSand the broader I&I portfolio.

• Support investigator identification, site engagement, and treatment-center collaboration to inform Phase 2 trial siteselectionand enrollment planning.

• Lead or co-lead advisory boards, investigator meetings, and congress activities (e.g., AAAAI) to gather external input and inform development andevidencegeneration priorities.

• Partner with Hematology,HEOR and Clinical Development on evidence generation planning to address stakeholder and future payer needs as thepipelineprogramsmature.

• Collaborate with External medical affairs counterparts to ensure aligned scientific messaging and engagement strategy under the co-development agreement.

• Partner with Regulatory, Legal, and Compliance to ensure all medical affairs activities are conducted within regulatory and compliance guardrails.

• Monitor the CSU,MSand broader I&I competitive and scientific landscape, translating insights into…