Postdoctoral Research Scientist, Gene Therapy Vector Engineering

Role Summary

The Postdoctoral Scientist in Gene Therapy vector engineering will participate in the development of novel AAV-based gene therapies and their process development. Working with Collaboration Partners and internal colleagues in Research, CMC, and Business Development, the individual will participate in work on new and existing programs.

• The primary role is to design and produce novel AAV material at various scales to advance gene therapy programs
• Design and execute molecular biology and in vitro experiments in support of AAV capsid and genome engineering
• Prepare data summaries and present results to peers and colleagues at Neurocrine
• Be able to present data as appropriate at scientific meetings at the National and International level
• Other tasks as assigned

• Proficient in molecular biology and cell culture work
• Experience with AAV production preferred, including plasmid transfection, cell material processing, and purification by ultracentrifugation
• Knowledge of AAV vector design including capsid and gene regulatory elements
• Backgrounds in neuroscience, protein engineering, and/or sequencing technologies are a plus
• General knowledge of AAV biology and/or protein engineering
• Experience with molecular biology techniques such as PCR, digital PCR, gel electrophoresis, western blot/ELISA, plasmid design, cloning, and sequencing
• Experience with cell culture in vitro techniques such as cell passage of adherent and suspension cells, sterile technique, media preparation, cell lysis, and material processing
• Experience with NGS sample preparation and data analysis
• Excellent critical analysis skills and ability to assess data and research findings outside of Neurocrine for application to new scientific projects
• Advanced knowledge and demonstrated ability to work with a variety of laboratory equipment/tools
• Ability to work as part of teams
• Excellent computer skills
• Excellent communication skills
• Ability to meet multiple deadlines across a variety of projects/programs, with a high degree of accuracy and efficiency

• Master's degree in biology, life sciences or related discipline, and experience in the biotech/pharmaceutical industry OR PhD or postdoc experience