Senior Research Associate, Protein Purification & Expression ~ Contractor

Senior Research Associate, Protein Expression

Nurix Therapeutics is a clinical stage biopharmaceutical company focused on the discovery, development, and commercialization of targeted protein degradation medicines, the next frontier in innovative drug design aimed at improving treatment options for patients with cancer and inflammatory diseases. Powered by a fully AI-integrated discovery engine capable of tackling any protein class, and coupled with unparalleled ligase expertise, Nurix’s dedicated team has built a formidable advantage in translating the science of targeted protein degradation into clinical advancements.

Nurix aims to establish degrader-based treatments at the forefront of patient care, writing medicine’s next chapter with a new script to outmatch disease.

Nurix Therapeutics, Inc. is seeking a detail-oriented and experienced Protein Expression Research Associate Contractor to join the DEL and Protein Sciences team. This individual will plan, coordinate, and execute all operational activities required for analytical scale and preparative scale expression of recombinant proteins in baculovirus and mammalian cell systems. They will also document expression conditions and results in internal databases and electronic lab notebook systems.

• Maintain insect cell and mammalian cell cultures.
• Manage all steps in baculovirus expression of recombinant proteins, including clone design, generation and purification of bacmids, raising and titering of baculovirus, conducting MOI studies, cell culture of Sf9 and/or Tni/Hi5 cells, and harvesting of biomass on the scale of 1 L – 20 L.
• Apply protein characterization techniques, including SDS‑PAGE analysis, size exclusion chromatography, and thermal stability assays (e.g., nanoDSF).
• Collaborate cross‑functionally with internal stakeholders to prioritize work across multiple projects.

• MS or equivalent with 2+ years of relevant experience, or Ph.D.
• 2+ years of experience working with insect cell lines and baculovirus expression of recombinant proteins; additional experience in mammalian cell expression (e.g., HEK
  293) is a plus.
• Industry experience preferred with demonstrated ability to over express milligram amounts of protein for structural and functional studies across multiple protein classes.
• Detail-oriented with strong record‑keeping skills.
• Experience purifying recombinant proteins (e.g., affinity chromatography, ion exchange, or size exclusion chromatography) is a bonus.
• Physical ability to lift 50 + pounds comfortably.
• Onsite position.

70 /hr – 81 /hr

• Strong team orientation; highly collaborative
• Solutions and results-oriented focus
• Hands‑on approach; resourceful and open to diverse points of view