Scientist, -Throughput Protein Expression and Purification

At Bristol Myers Squibb, our employees often ask, “Who are you working for?”—a question that fuels collaboration, accountability, and urgency in our work. Our purpose-driven culture inspires us to discover, develop, and deliver innovative medicines to prevail over serious diseases. We offer uniquely interesting and meaningful work, opportunities for growth, and a supportive environment that values inclusion, wellbeing, flexibility, and comprehensive benefits.

This is work that transforms the lives of patients, and the careers of those who do it.

We are seeking a highly motivated Scientist to expand high-throughput biologics production capabilities within Discovery Biotherapeutics. This hands‑on, laboratory-facing role will execute and advance scalable protein expression, purification, normalization, and characterization workflows that enable antibody, multispecific, and other biologics discovery programs. The successful candidate will bring practical experience in mammalian protein production and protein purification, with the ability to independently execute experiments, analyze data, troubleshoot workflows, and deliver high‑quality protein reagents.

The Scientist will work closely with Protein Sciences, Molecular Biology, Automation, Data Science, Discovery Biology, and project teams to align production activities with program priorities and experimental timelines. The ideal candidate thrives in a fast‑paced, collaborative environment, enjoys solving technical challenges, and is motivated to apply automation and emerging technologies to improve throughput, reproducibility, and cycle time. Experience with laboratory automation, cell‑free expression, workflow scripting, or closed‑loop discovery is preferred.

• Execute high-throughput protein production workflows supporting antibody, multispecific, and other biologics discovery programs.
• Design, optimize, and troubleshoot transient mammalian expression workflows at micro- and mid-scale using HEK
  293, CHO, or related systems.
• Perform automated and semi‑automated protein purification, sample normalization, and quality assessment to deliver fit‑for‑purpose protein reagents and therapeutic molecules.
• Operate, maintain, troubleshoot, and continuously improve liquid handlers, robotic workstations, automated purification systems, and associated analytical instrumentation.
• Develop robust, reproducible, and scalable workflows for protein expression, purification, normalization, and quality control.
• Plan and execute experiments, analyze and interpret scientific and operational data, document results, and communicate findings to cross‑functional teams and project stakeholders.
• Partner with Protein Sciences, Molecular Biology, Automation, Data Science, Discovery Biology, and project teams to coordinate production requirements, priorities, and timelines.
• Evaluate and implement emerging technologies, instrumentation, miniaturization strategies, and automation solutions that improve throughput, quality, reproducibility, and operational efficiency.
• Establish and maintain best practices, standard operating procedures, quality standards, and documentation that support data integrity, reproducibility, and safe laboratory operations.
• Lead or contribute to root‑cause analysis and resolution of workflow, production, and instrumentation issues, and implement corrective and preventive actions.
• Drive continuous‑improvement initiatives that reduce cycle time, increase workflow reliability, and expand platform capabilities.

Bachelor's degree in biochemistry, bioengineering, structural biology, molecular biology, or a related scientific discipline with 5 or more years of relevant academic and/or…