Senior Scientist -Degrader Antibody Conjugate Cellular Pharmacology

Senior Scientist - Degrader Antibody Conjugate Cellular

Nurix Therapeutics is a clinical stage biopharmaceutical company focused on the discovery, development, and commercialization of targeted protein degradation medicines, the next frontier in innovative drug design aimed at improving treatment options for patients with cancer and inflammatory diseases. Powered by a fully AI-integrated discovery engine capable of tackling any protein class, and coupled with unparalleled ligase expertise, Nurix’s dedicated team has built a formidable advantage in translating the science of targeted protein degradation into clinical advancements.

Nurix aims to establish degrader-based treatments at the forefront of patient care, writing medicine’s next chapter with a new script to outmatch disease.

We are seeking an accomplished scientific leaderwho will define and driveourin vitro screening and pharmacological characterization capability for Degrader Antibody Conjugates (DACs). Our DAC platform pairs antibody-based targeting with our degraderexpertiseto direct protein degradation to specific cell types, and this scientist willown theinvitro strategydefining how candidate molecules move through thescreeningcascade — fromprimary screening through mechanistic pharmacological characterizationofdrug candidates.

This is a hands-on leadership role for someone who has built deep expertise in the ADC and/or DAC field and wants toapply that experience in designing and runningin vitro pharmacology studies into ahighly collaborative discovery organization, while operating with a high degree of scientific independence. The scientist will independentlydesign, execute, and analyze cellular assays that characterize DAC activity, and will partner closely withdiscovery biology, conjugation chemistry,analyticalbiochemistry, DMPK, and automation to advance candidates from early screeningthrough development candidateselection.

Success depends as much on scientific vision, influence, and communication as on technical depth: the ideal candidate is self-driven, resourceful, and organized — a strong strategic thinker, an effective and compelling presenter, and a proven leader who can align and drive teams in a matrixed setting without relying on direct authority.

• Bring rich knowledge of the preclinical drug discoveryworkflowfor ADCs/DACsto shape integrated characterization plans, connectin vitro pharmacology toinvivoandtranslational strategy, andanticipatethe data packages needed for candidate progression.

• Design, build, anddrivethein vitro pharmacology and screeningframework forDACs and biologics, from primary screening through mechanistic and quantitative characterization.

• Serve asa key scientific decision-driver for DACin vitro pharmacology, providing sound judgment on assay strategy, data interpretation, and go/no-go recommendations.

• Lead and influence a matrixed, cross-functional organization, partnering with discovery biology, conjugation chemistry, analytical biochemistry, DMPK, andchemistryautomation to translate strategy into execution and to advance multiple programs in parallel.

• Leadthe design and execution of pharmacology studies, working closely with team members,to assess the biological activity and mechanism of action oflead molecules and drug candidates.

• Develop and perform cell-based assays to characterize DAC and biologic activity, includingantigen binding,target engagement, and targeted protein degradation,using cutting-edgetechnologiesand automated workflows.

• Cultivate andmaintainmammalian celllines(experiencemanipulating cell surfaceantigensand engineeringreporter linesused to characterize DACsispreferred).

• Stay current with the latest scientific literature and industry developments in the…